Spinocerebellar Ataxia Clinical Trial
The Cerebellum contains ten percent of the total volume of the brain and receives brain,
spinal cord and vestibular sensory input. The organization of vestibular and somato-sensory
afferent informations are also reported to be impaired in patients with cerebellum
dysfunctions. Ataxia and impaired balance control are common symptoms in individuals with
spinocerebellar ataxia (SCA). Previous studies have shown that patient with cerebellar
damage are usually agonist and antagonist muscle coordination problem. Past studies also
found the regulation of reciprocal Ia inhibition was impaired in patients with
spinaocerebellar ataxia. In chronic phase, weakness might be developed due to deconditioned.
All deficits mentioned above might lead to a decrease functional ability. Therefore,
increasing somato-sensory and vestibular input, normalizing the modulation of recriprocal
inhibition, and improve muscle strength might be able to improve the functional abilities of
individuals with SCA.
Recently, whole body vibration (WBV) has been trained for health groups. Studies showed that
WBV training were able to improve muscle strength, balance control, and functional ability.
However, there is no evidence showed that whether the whole body vibration training can
affect the brain and spinal cord for the regulation of neural circuits. Whether also can
affect for maximal voluntary contraction and improve central fatigue. No previous studies
that whole body vibration training for SCA.
Therefore, the purpose of this research was to investigate the intracortical facilitation
and inhibition, reciprocal Ia inhibition, low frequency depression, maximal voluntary
contraction, interpolated twitch technique to compare the different between the SCA and
health subject. Also to investigate the short term and long term effect of WBV.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
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| Completed |
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| Completed |
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| Recruiting |
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|
||
| Completed |
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|
N/A |