Slowing Down Disease Progression in Premanifest SCA: a Piloting Interventional Exergame Trial — SlowSCA  

Spinocerebellar Ataxia Clinical Trial

Official title: Slowing Down Disease Progression in Premanifest SCA: a Piloting Interventional Exergame Trial

Status Recruiting

Clinical Trial Summary

This is a piloting study using continuous motor training provided via whole body-controlled video games (exergames) to establish proof-of-concept evidence that such training leads to motor and neural changes in pre-manifest subjects with spinocerebellar ataxias (SCA).

Clinical Trial Description

In many neurodegenerative diseases, including spinocerebellar ataxias (SCA), large populations of neurons are already lost and compensatory resources exhausted at time of clinical diagnosis. This calls for early intervention strategies aiming to slow down disease progression already at the premanifest stage of the disease. Here we propose the world-first interventional study aiming to delay onset in a rare genetic neurodegenerative disease. Specifically, we propose a piloting study using continuous motor training provided via whole body-controlled video games (exergames) to establish proof-of-concept evidence that such training leads to motor and neural changes in pre-manifest SCA subjects. The subclinical effects will be unravelled within an intraindividual control study design by elaborated quantitative Video Management System (VICON®)-based movement analysis and structural and functional 3 Tesla (T) magnetic resonance imaging. This will provide unique insights in underlying motor and neural networks and compensatory strategies. If successful, this piloting trial will provide the basis for a rigorous international multi-center large-scale study in a larger SCA population. Moreover, it will stimulate complementary tandem projects on effects of motor training on neural functioning and molecular pathways in premanifest SCA mouse models. ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Related Conditions & MeSH terms

• Ataxia
• Disease Progression
• Spinocerebellar Ataxia
• Spinocerebellar Ataxias
• Spinocerebellar Degenerations

• NCT number: NCT02867969
• Study type: Interventional
• Source: University Hospital Tuebingen
• Contact: Matthis Synofzik, PD Dr.
• Phone: +49-7071-2982060
• Email: matthis.synofzik@uni-tuebingen.de
• Status: Recruiting
• Phase: N/A
• Start date: August 2016
• Completion date: May 2017