Spinal Cord Injury Clinical Trial
Official title:
A Multi-Centered, Randomized, Double-Blind, Placebo-Controlled Trial for Efficacy in the Use of Adjuntive Probiotic Therapy in Reducing Urinary Tract Infections in Those Individual With Spinal Cord Injury
We hypothesize that probiotic Lactobacillus can augment antibiotic treatment of symptomatic urinary tract infection (UTI) in spinal cord injured patients, and also increase the time to the next episode of UTI.
Subjects will be recruited from the outpatient population and 'alumni' of the Regional SCI
Rehabilitation Programs in London (Parkwood Hospital/St Joseph's Health Care) and Hamilton
(Hamilton Health Sciences Centre) Ontario.
Community living paraplegic and tetraplegic men and women (18 years and above) who present
to their family physician or specialist with symptomatic UTI will be prescribed an
antibiotic treatment for up to 14 days (using the drug of choice i.e. which the treating
physician deems appropriate) and randomized to also receive by mouth two capsules containing
placebo or probiotic Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 daily.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention
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