Brivaracetam to Reduce Neuropathic Pain in Chronic Spinal Cord Injury

Status Active, not recruiting

Clinical Trial Summary

Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to all pharmacological intervention. Preliminary data suggest brivarecetum is a mechanism-based pharmacological intervention for neuropathic pain in SCI. This randomized, placebo-controlled pilot clinical trial will assess feasibility of a 3-month treatment course with brivarecetum.

Clinical Trial Description

The investigations will assess changes in pain intensity and periaqueductal gray hyperactivity. Baseline periaqueductal gray hyperactivity and microRNA levels will be measured as potential biomarkers of response to treatment. These preliminary findings will be used to design larger clinical trials to establish efficacy of brivarecetum to treat neuropathic pain in SCI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04379011
Study type	Interventional
Source	University of Minnesota
Contact
Status	Active, not recruiting
Phase	Phase 1/Phase 2
Start date	February 1, 2021
Completion date	September 1, 2024

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