Changes in the Microvascular Reactivity on Leg During Spinal Anesthesia

Status Completed

Clinical Trial Summary

Anesthesia alters microcirculation and tissue oxygen saturation (StO2). We sought to examine changes in StO2 using near-infrared spectroscopy and a vascular occlusion test (VOT) during spinal anesthesia. This prospective observational study was included 51 patients without comorbidities who underwent elective surgery under spinal anesthesia. We measured the StO2 in the lower extremity during VOT before and after intrathecal injection.

Clinical Trial Description

The vascular occlusion test (VOT) procedure was conducted twice in each patient, before and 15 min after intrathecal injection. An near-infrared spectroscopy (NIRS) sensor (INVOSTM 5100C Cerebral/Somatic Oximeter; Medtronic, Minneapolis, MN, USA) was attached to the patient's gastrocnemius muscle. A tourniquet (A.T.S ® 3000 Automatic Tourniquet System; Zimmer Inc., Warsaw, IL, USA) was applied to the thigh and inflated to a pressure value 50 mmHg over the patient's baseline systolic blood pressure in the leg and maintained for 5 min. After a 5-min ischemic period, the tourniquet was rapidly deflated to 0 mmHg. The tissue oxygen saturation (StO2) data was continuously recorded during the VOT procedure. After confirmation of spinal anesthesia using cold sensitivity, the VOT procedure was repeated in the same manner as mentioned above. The occlusion slope and recovery slope were calculated based on the measured StO2 data. The occlusion slope was defined as the descending slope of StO2 value until it reached the minimum value. The recovery slope was calculated from the deflation of the tourniquet until the recovery of StO2 to the maximum value. ;

Study Design

Related Conditions & MeSH terms

Spinal Anesthesia

Clinical Trial Details

NCT number	NCT04806997
Study type	Observational
Source	Pusan National University Hospital
Contact
Status	Completed
Phase
Start date	December 29, 2016
Completion date	December 31, 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02565303` - Minimum Effective Dose of Ropivacaine for Spinal Anesthesia for Cesarean Delivery	N/A
Recruiting	`NCT03248817` - Phenylephrine Infusion in Cesarean Delivery	Phase 4
Completed	`NCT02840006` - Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass	Phase 4
Completed	`NCT01624844` - Predictive Value of Ultrasound Measurement of the Dural Sac Volume on the Sensory Level in Spinal Anesthesia	N/A
Recruiting	`NCT00974961` - Levobupivacaine on Heart Rate Variability (HRV) in Spinal Anesthesia	Phase 4
Recruiting	`NCT00492453` - Spinal Versus General Anesthesia for Laparoscopic Cholecystectomy	N/A
Completed	`NCT05549011` - PENG vs SIFI Block for Positioning Pain During Spinal Anesthesia
Completed	`NCT03805503` - Chloroprocaine for Inguinal Herniorrhaphy	Phase 4
Completed	`NCT03775655` - Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section	Phase 2/Phase 3
Completed	`NCT03199170` - Effect of Bilateral Quadratus Lumborum Block for Pain Relief in Patients With Cesarean Section	N/A
Completed	`NCT03302039` - Three Protocols for Phenylephrine Administration in Cesarean Delivery	Phase 4
Not yet recruiting	`NCT05063292` - Effect of Prewarming On Skin Temperature Changes	N/A
Not yet recruiting	`NCT05583214` - Evaluating the Effectiveness of Ondansetron Versus Dexamethasone Versus Placebo for the Control of Intraoperative Nausea and Vomiting in Patients Undergoing Lower-segment Caesarean Section Under Spinal Anesthesia	Phase 4
Recruiting	`NCT02937792` - Large Volume Bupivacaine 0.5% Versus Small Volume in Elective Caesarean Section	N/A
Recruiting	`NCT01415284` - ED50 Determination of Hydroxyethylstarch for Treatment of Hypotension During Cesarean Section Under Spinal Anesthesia	Phase 4
Completed	`NCT00537472` - Low Dose Spinal Bupivacaine for Total Knee Replacement and Recovery Room Wait Time	N/A
Completed	`NCT05548985` - Midodrine for Prophylaxis Against Post Spinal Hypotension in Elderly Population	N/A
Completed	`NCT03322098` - Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Geriatric Patients Undergoing Total Knee Replacement Under Spinal Anesthesia	N/A
Recruiting	`NCT04598061` - IV Dexmedetomidine as Spinal Anesthesia Adjuvant in Infants
Completed	`NCT04083768` - Effect of Different Left Lateral Table Tilt for Elective Cesarean Delivery Under Spinal Anesthesia	N/A