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Evaluation of muLtimodal and Non-invasive SPINa Bifida Neurovessels During Prospective Follow-up — SPINLESS  

Spina Bifida Clinical Trial

Official title:
Evaluation of muLtimodal and Non-invasive SPINa Bifida Neurovessels During Prospective Follow-up

Clinical Trial Summary

The aim of the study is to investigate known urinary biomarkers in order to determine whether they can be predictive of a risk of damage to the upper urinary tract and therefore the kidneys in patients with spina bifida. The risk of damage to the upper urinary tract can be calculated using the Galloway score, based on the results of the urodynamic study and retrograde urethrocystography, which all patients with spina bifida have regularly. The urinary biomarkers studied TIMP-2 (Tissue inhibitor of metalloproteinases 2) and MMP-2 (matrix metalloproteinase-2) are potentially associated with renal degradation, but this has not yet been demonstrated. Volunteers to take part in the study will have their biomarkers measured at the time of their urodynamic assessment.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06041334
Study type Interventional
Source Rennes University Hospital
Contact LOÏC JACOB
Phone 0299282555
Email loic.jacob@chu-rennes.fr
Status Recruiting
Phase N/A
Start date January 18, 2024
Completion date January 18, 2026
View Details
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