Somatosensory Disorders Clinical Trial
Background: Several studies have indicated that infants who had undergone postnatal painful
procedures appear to be hypersensitive to pain, with a lower threshold to tactile
stimulations later on life.
Objective: To study the effect of early exposure to pain on cerebral somatosensory evoked
potential (SEP) response to thermal stimulation (550C), in preterm and full term born
adolescents (15-18 years old), who have undergone painful procedures during their neonatal
period. As well as to study the effect of early exposure to thermal and tactile sensory
thresholds and pain thresholds to thermal and tactile stimuli, by using the TSA and von Frey
hairs.
Design: Case-control study.
Participants: Four groups of 20 adolescents (aged 15-18 years), two of which are full term
and preterm-born who were exposed to painful procedures during the neonatal period. The
other two groups are term and preterm-born adolescents who were not exposed to such
procedures.
Main Outcome Measures: Cerebral SEP response (P300, Medoc Ltd., Israel) to thermal
stimulation (550C). Warm-sensation threshold (WST), heat-pain threshold (HPT), Cold
sensation threshold (CST) and cold pain threshold (CPT) by using Thermal sensory analyzer
(TSA-2001,Medoc Ltd., Israel). Pain threshold to tactile stimulation will be measured by
using Von-Frey hairs.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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