Solitary Pulmonary Nodule Clinical Trial
— mLOWEROfficial title:
Mobile Lung Nodule Observatory for Worldwide, Evidenced - Based Research
NCT number | NCT02693496 |
Other study ID # | CAALC-002-mLOWER |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | October 2015 |
Est. completion date | October 2025 |
Patients with lung nodules may develop a variety of potentially severe symptoms. These symptoms may impact a patient's quality of life and lead to difficult treatment. Through this research program, the investigators want to understand the pathogenesis of the changes of these symptoms.
Status | Recruiting |
Enrollment | 10000 |
Est. completion date | October 2025 |
Est. primary completion date | October 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility |
Inclusion Criteria: - Age between 18 and 90 - There is a chest lesion less than 3cm width (examined by Thin-Section CT) - The patient or his family member owns a smartphone - Signed informed consent - Completed the installation and registration of mobile terminal software online - Willing to complete a 10-year period of follow-up Exclusion Criteria: - Not equipped with a smartphone - Cannot complete the installation or registration of smartphone application software online - Received prior chemotherapy medications for lung cancer or received lung surgical removal treatment |
Country | Name | City | State |
---|---|---|---|
China | Beijing Union Hospital | Beijing | |
China | General Hospital of PLA | Beijing | |
China | Hebei Pronvince Cangzhou City People's Hospital | Cangzhou | |
China | Xiaya Hospital Central South Unversity | Changsha | |
China | Anhui Province Chaoyang Hospital | Chaoyang | |
China | West China Hospital Sichuan University | Chengdu | |
China | No.1 Hospital Chongqing Medical University | Chongqing | |
China | Western East Hospital No. 3 PLA Medical University | Chongqing | |
China | No. 2 Hospital Dalian Medical University | Dalian | |
China | Guizhou Province People's Hospital | Guizhou | |
China | International Hospital Zhejiang University | Hangzhou | |
China | No. 1 Hospital Zhejiang University Medical College | Hangzhou | |
China | Yunnan Province Cancer Hospital | Kunming | |
China | Shandong Province Liaocheng City People's Hospital | Liaocheng | |
China | No. 2 Hospital Fujian Medical University | Quanzhou | |
China | Kecheng District Hospital | Quzhou | |
China | Minhang District Hospital Fudan University | Shanghai | |
China | Putuo District Central Hospital Shanghai Chinese Medical University | Shanghai | |
China | Ruici Clinic | Shanghai | |
China | Shanghai Zhongshan Hospital | Shanghai | |
China | No. 2 Hospital Tianjin Chinese Medical University | Tianjin | |
China | Weifang City No.2 People's Hospital | Weifang | |
China | Wudang Hospital Guiyang Medical College | Wudang | |
China | Wuhu City No. 2 Hopsital | Wuhu | |
China | No. 5 Wuxi People's Hospital | Wuxi | |
China | Xiamen City No.3 People's Hospital | Xiamen | |
China | Xining Hospital No.4 PLA University | Xian | |
China | Yantai City Taishan Hopsital | Yantai | |
China | Henan Province People's Hospital | Zhengzhou | |
China | No. 1 Hospital Zhengzhou University | Zhengzhou | |
China | Shandong Pronvince Zibo City Official Hospital | Zibo | |
China | Shandong Province Linzi District Hospital | Zibo | |
China | Sichuan Province Zigong City No. 1 Hospital | Zigong | |
China | Guizhou Province Zunyi Medical College Hospital | Zunyi |
Lead Sponsor | Collaborator |
---|---|
Chinese Alliance Against Lung Cancer |
China,
Gould MK, Donington J, Lynch WR, Mazzone PJ, Midthun DE, Naidich DP, Wiener RS. Evaluation of individuals with pulmonary nodules: when is it lung cancer? Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013 May;143(5 Suppl):e93S-e120S. doi: 10.1378/chest.12-2351. Review. — View Citation
Yang DW, Zhang Y, Hong QY, Hu J, Li C, Pan BS, Wang Q, Ding FH, Ou JX, Liu FL, Zhang D, Zhou JB, Song YL, Bai CX. Role of a serum-based biomarker panel in the early diagnosis of lung cancer for a cohort of high-risk patients. Cancer. 2015 Sep 1;121 Suppl 17:3113-21. doi: 10.1002/cncr.29551. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | To compare the diagnostic accuracy among different type of lung nodules. | Utilizing the professional statistical software (SPSS 15.0), through T-test, Mann-Whitney U test, and analyzing the receiver operating characteristic (ROC) curve, to compare the diagnostic accuracy among different type of lung nodules. A p<0.05 cutoff will be the standard used to determine statistical significance. | 10 years |
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