| Eligibility |
Inclusion Criteria:
1. Patients aged = 18 years with pathologically or cytologically confirmed metastatic or
unresectable advanced solid tumors that progressed despite standard of care or which
did not tolerate standard of care and for which other standard of care is not
available.
2. Patients with the following laboratory test values, obtained within 14 days prior to
study enrollment with no history of G-CSF or blood transfusions within 14 days prior
to collection of samples for the laboratory tests:
- ANC = 1,500/mm³
- Platelet count = 100,000/mm³
- Hemoglobin = 9.0 g/dL
- CrCl = 60 mL/min calculated using the Cockcroft-Gault formula ?
Total bilirubin = 1.5×ULN ? AST, ALT = 3×ULN (= 5×ULN for patients
with liver metastasis or liver cell carcinoma) ? INR and aPTT =
1.5×ULN ? Urine protein to creatinine ratio (UPC) < 1.0 (g/g)a a
UPC will be performed in patients with at least one positive (+)
protein outcome upon urinalysis.
3. At least one evaluable lesion based on the response evaluation criteria in solid
tumors (RECIST) version 1.1 as measured by tumor markers or CT/MRI.
4. Life expectancy = 12 weeks.
5. Eastern Cooperative Oncology Group (ECOG) performance status = 2.
6. Women of childbearing potential who test negative for pregnancy (by serum-hCG or
urine-hCG at the discretion of the investigator) at the time of study participation
(i.e., all women who have had menarche and are not surgically sterile [hysterectomy,
bilateral tubal ligation, bilateral ovariectomy, etc.] and are not post-menopausal [no
menstruation for = 12 months for no other medical reasons]).
7. Patients who agree to use medically acceptable methods of birth control (patient's or
partner's vasectomy, tubal ligation, intrauterine device, barrier contraception, oral
contraceptives, diaphragm or condom use in combination) during treatment with the
investigational product (IP) and for 6 months after the end of treatment.
8. Patients who voluntarily provide written informed consent to participate in the study.
Exclusion Criteria:
1. History of hypersensitivities to any of the components of the IP or the same class of
drugs as the IP.
2. At the time of the 1st treatment:
- < 4 weeks from a major surgery, if applicable
- < 2 weeks from a minor surgery, if applicable
- < 3 weeks from the last radiotherapy, if applicable
- < 5 x half-life or < 3 weeks, whichever is longer, from chemotherapy or hormone
therapy, if applicable (those who were treated with nitrosoureas or mitomycin
within 6 weeks prior to the 1st treatment or targeted biological antibodies
within 4 weeks prior to the 1st treatment were not allowed to participate in the
study.)
- < 4 weeks from anticancer immunotherapy, if applicable
3. History of cardiovascular disorders within the past 5 years:
- New York heart association (NYHA) class = II (or left ventricle ejection fraction
= 50%) congestive heart failure (CHF)
- Uncontrolled hypertension (systolic blood pressure [SBP]/diastolic blood pressure
[DBP] > 140/90 mmHg)
- History of hypertensive crisis or hypertensive encephalopathy
- Pulmonary hypertension
- Myocardial infarction
- Significant vascular disease (e.g., aortic aneurysm requiring surgery or recent
peripheral artery thrombosis) within 6 months prior to IP initiation
- Uncontrolled arrhythmia
- QTcF interval > 470 msec on screening electrocardiogram (ECG)
4. Clinically significant NCI-CTCAE v5.0 Grade = 1 (allowing Grade = 2 alopecia) ongoing
toxicities from previous anticancer treatment.
5. Severe infection or severe traumatic systemic disorders.
6. Symptomatic or uncontrolled metastasis to central nervous system (CNS) (a patient with
asymptomatic CNS metastasis may participate in the study if systemic corticosteroids
were discontinued = 4 weeks prior and the patient is radiologically and neurologically
stable for = 4 weeks).
7. Severe neurological or psychiatric disorders that might have an impact on study
results in the opinion of the investigator.
8. Pregnant or lactating women or patients planning a pregnancy during the study period.
9. Participation in another clinical trial within 30 days prior to the 1st treatment.
10. History of bleeding or digestive disorders:
- Evidence of active bleeding, bleeding diathesis, coagulopathy, or tumor with
macrovascular invasion
- Clinically significant digestive ulcer, gastrointestinal (GI) bleeding, GI or
non-GI fistula, perforation, intra-abdominal abscess, clinical symptoms and signs
of GI obstruction, patients requiring parenteral fluids or nutrition, history of
digestive disorders such as inflammatory bowel disease
- Evidence of pneumoperitoneum unexplained by recent surgery or paracentesis
11. Treatment with biguanides (e.g., metformin) within 2 weeks prior to the 1st treatment
or anticipated required treatment with biguanides during the study period.
12. Patients requiring continuous treatment with systemic corticosteroids. However, the
following will be permitted:
- Use of local corticosteroids such as local intra-articular, intra-nasal,
intra-ocular, or inhaled corticosteroids or temporary use of systemic corticosteroids
for the treatment and prevention of adverse events (AEs) or allergic reactions to
contrast agents will be permitted.
13. Patients with HIV and other severe diseases that would limit a patient's participation
in the study in the opinion of the investigator (medically controlled diseases will be
permitted).
14. Having ascites and/or pleural fluid drained within 14 days prior to screening.
15. Hemoptysis within 14 days prior to screening (= 1/2 teaspoonful cherry red blood per
episode).
16. Core biopsy or any other minor surgical procedure within 14 days prior to initial IP
dose (except for placing a vascular access).
17. Serious, unhealed scars, active ulcers, or untreated fractures.
18. History of cerebrovascular accident (stroke), transient ischemic attack, or
subarachnoid hemorrhage within 6 months prior to screening.
19. History of glucose-6-phosphate dehydrogenase deficiency.
20. Individuals ineligible for this study for other reasons in the opinion of the
investigator.
21. Patients identified with hypercalcemia (corrected calcium concentration > 10.4 mg/dL
(2.6mmol/L)) identified during the screening period.
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