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Solid Tumor clinical trials

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NCT ID: NCT06384807 Not yet recruiting - Solid Tumor Clinical Trials

A Phase 1/2 Study of PBI-410 in Advanced Solid Tumors

Start date: April 2024
Phase: Phase 1/Phase 2
Study type: Interventional

This is a Phase 1/2, first in human (FIH), open-label, multicenter study of PBI-410 in participants with previously treated, advanced solid tumors.

NCT ID: NCT06375187 Not yet recruiting - Breast Cancer Clinical Trials

Engineering Tumor Infiltrating Lymphocytes Injection (GC203 TIL) for the Treatment of Advanced Malignant Solid Tumors

KUNLUN-001
Start date: May 1, 2024
Phase: Phase 1
Study type: Interventional

A clinical trial to assess the safety and efficacy of engineered Tumor Infiltrating Lymphocytes (TIL) for the treatment of Advanced Malignant Solid Tumors

NCT ID: NCT06349837 Not yet recruiting - Solid Tumor Clinical Trials

Safety and Tolerability of LDRT Plus Concurrent Partial SBRT and Tislelizumab in Patients With Bulky Tumors

Start date: April 15, 2024
Phase: Phase 1
Study type: Interventional

This is a 3+3 dose escalation phase I study which aims to evaluate the safety and tolerability of low dose radiotherapy (LDRT) plus concurrent partial Stereotactic Ablative Radiotherapy (SBRT) and Tislelizumab in Patients with bulky tumors who have failed standard therapy. At least 9 participants will be enrolled in this study.

NCT ID: NCT06337630 Not yet recruiting - Solid Tumor Clinical Trials

A Study on Tuvusertib (Oral ATR Inhibitor) in Combination With PLX038 (Topo1 Inhibitor) in Patients With Advanced Solid Tumors

POP-ART
Start date: June 15, 2024
Phase: Phase 1
Study type: Interventional

Phase I with a dose finding cohort, followed by expansion cohorts in pre-specified tumor types.

NCT ID: NCT06336148 Not yet recruiting - Solid Tumor Clinical Trials

A Phase 1a/1b Study of ACTM-838 in Patients With Advanced Solid Tumors

Start date: April 2024
Phase: Phase 1
Study type: Interventional

This is a first in human (FIH) 2-part study using ACTM-838 in patients with advanced solid tumors resistant to standard of care treatment. Part 1a will evaluate dose escalation and Part 1b will evaluate dose expansion.

NCT ID: NCT06332430 Not yet recruiting - Lymphoma Clinical Trials

Intratumoral CAN2109 in Subjects With Solid Tumors or Lymphomas

Start date: May 30, 2024
Phase: Phase 1
Study type: Interventional

A phase 1, dose escalation, open-label study of intratumoral CAN2109 in subjects with unstable or metastatic advanced solid tumors or lymphomas.

NCT ID: NCT06310655 Not yet recruiting - Solid Tumor Clinical Trials

Online Proton Adaptive Radiotherapy

PARTy
Start date: April 30, 2024
Phase: N/A
Study type: Interventional

This is a pilot study evaluating the feasibility of daily online adaptive planning for patients undergoing proton radiation therapy. Patients undergoing proton radiation therapy normally undergo extensive pre-planning for their treatment. However, accounting for uncertainties in treatment delivery remains a challenge for a variety of reasons, such as differences in patient anatomy from pre-planning to the day of treatment. Online adaptive planning is a process consisting of generating the original pre-plan on the patient on a treatment day, assessing the pre-plan's coverage and safety, and if changes are needed, the plan is changed in order to optimize the treatment while the patient is still on the treatment table. This study is assessing the feasibility and safety of this approach in order to gather data for a larger trial.

NCT ID: NCT06297525 Not yet recruiting - Solid Tumor Clinical Trials

Study of STP938 in Advanced Solid Tumours

Start date: September 2024
Phase: Phase 1
Study type: Interventional

The Phase 1a part of the study is a dose escalation of STP938 as a monotherapy. The Phase 1b part of the study is a safety expansion cohort of STP938 as a monotherapy.

NCT ID: NCT06245018 Not yet recruiting - Solid Tumor Clinical Trials

A Trial to Evaluate the Safety and Preliminary Efficacy of iNK in the Treatment of Subjects With Solid Tumor

Start date: February 1, 2024
Phase: N/A
Study type: Interventional

This trial is to investigate the safety, efficacy of iNK in subjects with solid tumor. It is a dose escalation and extension trial.

NCT ID: NCT06239298 Not yet recruiting - Solid Tumor Clinical Trials

A Study of ZG005 Combined With Donafenib in Patients With Advanced Solid Tumor

Start date: May 2024
Phase: Phase 1/Phase 2
Study type: Interventional

This is a Multi-center, Open-labe, Phase I/II Study to evaluate the safety and tolerability of ZG005 Combined With Donafenib in Patients With Advanced Solid Tumor.