| Eligibility |
Inclusion Criteria:
1. Diagnosed and histopathologically confirmed as high histologic grade soft-tissue
sarcoma, including undifferentiated pleomorphic sarcoma (UPS), liposarcoma(LPS),
leiomyosarcoma (LMS), synovial sarcoma (SS), alveolar soft-part sarcoma (ASPS), clear
cell sarcoma (CCS).
2. Upper limb (including shoulder), lower limb (including hip) and pelvic soft-tissue
sarcoma,
3. Age = 18 years,
4. High risk of local recurrence was defined if the largest diameter of tumor >5cm and
had at least one of below characters (1) Tumor border close (<5mm) to vital tissue
(vessel and nerve) from diagnostic MRI (2) MRI shows infiltrative tumor grow type
('focal-type' and 'diffuse-type') (3) Positive microscopic margins or macroscopic
residual (4) Recurrent tumor form previous treatment High risk of recurrence must be
assessed by staff including a surgeon specialized in sarcoma,
5. Eastern Cooperative Oncology Group (ECOG) performance status = 2,
6. Only one lesion, and can be accurately measured at baseline as = 5cm in the longest
diameter with magnetic resonance imaging (MRI) and which is suitable for accurate
repeated measurements according to RECIST 1.1,
7. Adequate hematological, renal, metabolic and hepatic function:
Haemoglobin = 9 g/dL and no blood transfusions in the 14 days prior to study entry
Absolute neutrophil count (ANc) = 1.5 x 109/L Platelets = 100 x 109/L Total bilirubin
= 1.5 x upper limit of normality (ULN), Alanine aminotransferase (ALAT) or aspartate
aminotransferase (ASAT) = 2.5 x ULN, Serum creatinine = 150 µmol/L or creatinine
clearance = 50 mL/min (according to local institution) in case of serum creatinine >
150 µmol/L, TP, INR = 1.5 x ULN
8. Patient is willing and able to comply with the protocol for the duration of the study
including undergoing treatment and scheduled visits and examinations including follow
up,
9. Voluntary signed and dated written informed consent prior to any specific procedure,
10. Patients have a life expectancy of more than 2 years with appropriate therapy,
11. All institutional, Food and Drug Administration (FDA), and National Cancer Institute
(NCI) requirements for human studies must be met.
Exclusion Criteria:
1. Any previous treatment, including chemotherapy, radiotherapy and target therapy,
within 6 months from the last time prior to study treatment,
2. Soft-tissue sarcoma occurred at head and neck, visceral organs, retroperitoneum,
peritoneum, pelvis within the confines of the bony pelvis
3. Patients with the following entities were excluded: GIST, rhabdomyosarcoma,
chondrosarcoma, osteosarcoma, dermatofibrosarcoma protuberans, Ewing sarcoma,
primitive neuroectodermal tumor, inflammatory myofibroblastic tumor, and malignant
mesothelioma.
4. Patients unable to swallow orally administered medication and patients with
gastrointestinal disorders likely to interfere with absorption of the study
medication,
5. Immunocompromised patients, e.g., patients who are known to be serologically positive
for human immunodeficiency virus (HIV) and are receiving antiviral therapy,
6. Patients with known active hepatic disease (i.e., Hepatitis B or C) due to risk of
transmitting the infection through blood or other body fluids,
7. Patients considered a poor medical risk due to a serious, uncontrolled medical
disorder, non-malignant systemic disease or active, uncontrolled infection. Examples
include, but are not limited to, uncontrolled ventricular arrhythmia, recent (within 3
months) myocardial infarction, unstable spinal cord compression (untreated and
unstable for at least 28 days prior to study entry), superior vena cava syndrome,
extensive bilateral lung disease on HRCT scan or any psychiatric disorder that
prohibits obtaining informed consent,
8. Patients with uncontrolled seizures,
9. Women of childbearing potential who are not using an effective method of
contraception; women who are pregnant or breast feeding,
10. No prior or concurrent malignant disease diagnosed or treated in the last 2 years,
11. Resting ECG with QTc > 470msec on 2 or more time points within a 24 hour period or
family history of long QT syndrome,
12. Blood transfusions within 14 days prior to study start,
13. Patients with myelodysplastic syndrome/acute myeloid leukaemia,
14. Major surgery within 6 months of starting study treatment and patients must have
recovered from any effects of any major surgery,
15. Participation to a study involving a medical or therapeutic intervention in the last 3
months,
16. Patient unable to follow and comply with the study procedures because of any
geographical, familial, social or psychological reasons,
17. Previous enrollment in the present study,
18. Patients with a known hypersensitivity to study medicines or any of the excipients of
the product,
19. Patients with metastasis.
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