Sodium Thiosulfate Clinical Trial
Official title:
Treatment of Ectopic Calcification / Ossification With Sodium Thiosulfate (CATSSO)
Ectopic calcification and ossification complicate many diseases, which are rare for the most
part. These calcifications (or ossifications) are generally classified according to their
apparent formation mechanism. Even if very different diseases can be at the origin, these
calcifications (or ossifications) have as common points: an unknown physiopathology, a
composition of calcium pyrophosphate for the most part and l no curative treatment validated
to date.
Indeed, although several reported cases suggest the potential efficacy of different
treatments , none of these treatments is currently recognized as effective because of the
absence of confirmation data or because of contradictory results.
Sodium thiosulfate (STS) has been used for a long time as an antidote to cyanide poisoning
and as a protective agent against cytotoxic side effects such as ifosphamide. More recently,
STS has been reported in the treatment of renal calcification. vascular or even subcutaneous.
First prospective studies on animal models and in humans seem to confirm the interest of this
product in the treatment of these abnormal calcifications.
For several months, a magistral preparation in the form of ointment based on STS has been
developed by the pharmacy of Limoges University Hospital in order to combine the local effect
of STS while avoiding the side effects of an administration of this treatment by systemic
way. The first uses of this preparation appear promising and some preliminary results have
already been published. The benefit / risk ratio of this approach seems to be advantageous
for clinicians since preparations whose composition is close are currently validated by the
FDA and the World Health Organisation for the treatment of benign pathologies such as
cutaneous dermatophytes or pityriasis versicolor.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04251832 -
Efficacy of Sodium Thiosulfate in Shoulder Pain in Calcific Tendinitis of the Rotator Cuff
|
Phase 2 |