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Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers

Smoking Clinical Trial

Official title:
Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers

Clinical Trial Summary

Regular aspirin use has been associated with a reduction in the development of a number of different malignancies including lung cancer. The mechanism of aspirin's cancer prevention is not known. This study will evaluate whether once daily aspirin use can reduce the production of a protein named prostaglandin E2 (PGE-2), which is known to promote cancer. Specifically, this study will evaluate if aspirin can inhibit the production of PGE-2 by blocking an enzyme named cycloxygenase-2 (COX-2). To accomplish these goals, participants will take either aspirin 325 mg daily, celecoxib 200 mg twice daily, or the combination of both during various days of this 16-day study. Urine be collected to evaluate for PGE-2 production at 4 timepoints in this 16-day study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01796951
Study type Interventional
Source Vanderbilt University Medical Center
Contact
Status Completed
Phase Early Phase 1
Start date February 2013
Completion date February 2016
View Details
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