Smoking Clinical Trial
Official title:
Effect of Resistance Training on Tobacco-Related Cardiovascular Disease Risk
This project is prompted by the urgent public health need to identify novel strategies to
prevent and treat tobacco-related cardiovascular disease (CVD) and by compelling pilot data
that suggests cessation of smoking results in rapid amelioration of endothelial function.
The higher prevalence of CVD and metabolic syndrome in smokers have become major health care
concerns. Therefore, finding optimal intervention strategies to combat these growing
epidemics is imperative. We are investigating the efficacy of resistance training to
ameliorate endothelial dysfunction, oxidative stress, inflammation, and insulin resistance
in four groups: presence or absence of resistance training with or without cessation
treatment + nicotine replacement.
The investigators hypothesize that resistance training will improve cardiovascular function
in smokers; however, the responses will be better in those who also stop smoking. In
addition, resistance training will decrease smoking, however, the effects of counseling and
nicotine replacement alone or counseling and nicotine replacement in conjunction with
resistance training will be better than resistance training alone.
The investigators are conducting a 12-week randomized-controlled trial of 100 young adult
smokers.
At week 0, participants attend three outpatient visits at baseline. Each participant is
randomized to one of four groups: Resistance Training(RT)/Nicotine Replacement Therapy
(NRT), RT/No NRT, No RT/NRT, and No RT/No NRT. Those receiving RT work with a certified
personal trainer 3 times per week for 12 weeks at 60 minutes each session. Those receiving
NRT use the nicotine patch daily for 12 weeks and call the California Smoker's Helpline for
smoking cessation counseling. Those in the control group do not receive any intervention and
maintain their current lifestyle and habits.
At week 13, participants return for three post-intervention assessments.
At week 26, survey data is collected to assess changes in lifestyle habits.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment
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