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HIV-1 and Brain Interaction on Smoking Comorbidity

Smoking Clinical Trial

Official title:
HIV-1 and Brain Interaction on Smoking Comorbidity

Clinical Trial Summary

People living with HIV-1 have high rates of cigarette smoking, which may be related to nicotinic interaction with HIV-1 infection and brain function levels. The proposed project aims to understand these pathways using translational brain imaging and HIV-1 reactivation studies. The study proposes a targeted nicotine-brain investigation of the nicotinic effects in HIV-1 infection from cellular to brain circuitry levels.

Clinical Trial Description

Smoking remains the leading cause of preventable morbidity and mortality in the United States. The alarmingly high smoking rates and unsatisfactory performance of standard smoking cessation efforts in people living with HIV/AIDS (PLWH) interfere with the overall progress in the treatment of HIV-1 infection. Our understanding of nicotine addiction mechanisms in PLWH, and how they are related to and interact with HIV-1 neuropathology, is limited and thus hindering the development of more effective, targeted treatments. The study will directly address neurological complication of this HIV-associated comorbidity at the brain circuitry level using state-of-the-art imaging tools and methods. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03308331
Study type Interventional
Source University of Maryland, Baltimore
Contact
Status Withdrawn
Phase N/A
Start date December 1, 2019
Completion date October 30, 2025
View Details
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