Lymphoma Clinical Trial
Official title:
In Vivo Imaging of Effector Cells in Anti-Lymphoma Therapy
RATIONALE: Measuring the number of radiolabeled white blood cells in non-Hodgkin's lymphoma
tumors may help doctors predict how well patients will respond to treatment, and may help
the study of cancer in the future.
PURPOSE: This study is measuring radiolabeled white blood cells in patients with
non-Hodgkin's lymphoma.
OBJECTIVES:
- Determine the number of indium In 111-labeled peripheral blood mononuclear cells
(PBMCs) and indium In 111-labeled polymorphonuclear leukocytes (PMNLs) trafficking into
lymphoma tumors prior to therapy in patients with non-Hodgkin's lymphoma.
- Compare the number of PBMC and PMNL trafficking prior to vs after therapy in these
patients.
- Compare, preliminarily, the number of in vivo baseline (i.e., pre-therapy) trafficking
of PBMCs vs PMNLs in these patients.
- Gather important data regarding the inter- and intra-patient variability of effector
cell trafficking into these tumors.
- Assess the relationship between response at 8-12 weeks and the magnitude of baseline
effector cell trafficking or the magnitude of post-rituximab effector cell trafficking
in these patients.
OUTLINE: This is a multicenter study. Patients are assigned to 1 of 2 groups.
- Group I: Patients receive autologous indium In 111 (^111In)-labeled peripheral blood
mononuclear cells on day 0.
- Group II: Patients receive autologous ^111In-labeled polymorphonuclear leukocytes on
day 0.
In both groups, patients undergo blood collection on day 0. Patients then undergo full-body
single-photon emission-computed tomography (SPECT) scan 4 hours after cell infusion and on
day 2. The labeling and imaging process may be repeated after at least 1 course of
anticancer treatment.
Cellular uptake is measured by reader/visual interpretation, a semiquantitative grading
system, and tumor-to-background uptake ratios.
PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study.
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