Sleep Clinical Trial
Official title:
The Impact of Sleep Restriction on Physical Performance, Markers of Muscle Damage, Inflammation, and Brain-derived Neurotrophic Factor (BDNF) Levels in Female Soccer Players.
This research aims to investigate the interplay between menstrual cycles, sleep patterns, and athletic performance. Before experimental sessions, participants will maintain menstrual diaries for three months and complete assessments for sleep disorders and chronotype. Sleep duration will be objectively measured over five nights using actigraphy, complemented by sleep-related data from an actigraph and the Karolinska Sleep Diary. The study involves two sessions: normal sleep (based on habitual duration) and restricted sleep (reduced by 3 hours). Athletes will engage in a simulated match-play game before both sessions, followed by comprehensive performance tests the next day. Blood samples will be collected at three intervals to analyze hormonal profiles (including progesterone, and estradiol), markers of muscle damage, inflammation, stress (such as TNF-α, IL-6, CRP, myoglobin, cortisol, testosterone), and brain-derived neurotrophic factor (BDNF). On Day 1, pre- and post-training blood samples will be obtained, and participants will wear an actigraph, adhere to specified bedtime routines, and report activities (restricted sleep group). Day 2 involves completing a sleep diary, refraining from caffeine, responding to questionnaires assessing readiness to train and mood, and undergoing performance tests followed by self-reporting of pain levels and perceived exertion using established scales (VAS, RPE 6-20).
Status | Recruiting |
Enrollment | 20 |
Est. completion date | June 2024 |
Est. primary completion date | June 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 16 Years to 30 Years |
Eligibility | Inclusion Criteria: - a minimum of 5 years of training experience - practicing physical activity for the last 6 months at least 3 times per week for 2h - current medical qualification for competitive sport Exclusion Criteria: - diseases that can have a bad influence on the menstrual cycle (e.g. polycystic ovarian syndrome, endometriosis); - using hormonal contraception; - regularity of the menstrual cycle. - diagnosed cardiovascular, metabolic, gastrointestinal, or neurological diseases; movement, neuromuscular or musculoskeletal disorders; - taking medications and supplements that may affect fitness test results; taking supplements that may affect biochemical test results - sleep disorders (PSQI >5) |
Country | Name | City | State |
---|---|---|---|
Poland | The Academy of Physical Education in Krakow | Krakow | |
Poland | University School of Physical Education in Cracow | Kraków |
Lead Sponsor | Collaborator |
---|---|
University School of Physical Education, Krakow, Poland | Jagiellonian University |
Poland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Objective Sleep - Total sleep time | Total sleep time obtained from sleep onset to time at wake-up assessed by actigraphy | 1 day after night with or without intervention. The night before and after the experimental sessions | |
Other | Objective Sleep - Sleep efficiency | The percentage of total sleep time to lights off and leaving bed assessed by actigraphy | 1 day after night with or without intervention. The night before and after the experimental sessions | |
Other | Objective Sleep - WASO (Wake After Sleep Onset) | The total number of minutes that a person is awake after having initially fallen asleep assessed by actigraphy | 1 day after night with or without intervention. The night before and after the experimental sessions | |
Other | Objective Sleep - Sleep duration | The quantity of time that a person sleeps assessed by actigraphy | 1 day after night with or without intervention. The night before and after the experimental sessions | |
Other | Objective Sleep - Sleep onset time | The time it takes a person to fall asleep after turning the lights out assessed by actigraphy | 1 day after night with or without intervention. The night before and after the experimental sessions | |
Other | Objective Sleep - Wake time | The hours in the day that a person is awake assessed by actigraphy | 1 day after night with or without intervention. The night before and after the experimental sessions | |
Other | Blood collection - progesterone | Blood will be drawn to measure progesterone | 1 day after night with or without intervention. Before each experimental sesion | |
Other | Blood collection - estradiol | Blood will be drawn to measure estradiol | 1 day after night with or without intervention. Before each experimental sesion | |
Other | Blood collection - cortisol | Before and after the match simulation and before the experimental session on the second day 1 day after night with or without intervention. | ||
Other | Blood collection - testosterone | 1 day after night with or without intervention. Before and after the match simulation and before the experimental session on the second day | ||
Other | Blood collection - TNF-a | 1 day after night with or without intervention. Before and after the match simulation and before the experimental session on the second day | ||
Other | Blood collection - IL-6 | 1 day after night with or without intervention. Before and after the match simulation and before the experimental session on the second day | ||
Other | Blood collection - CRP | 1 day after night with or without intervention. Before and after the match simulation and before the experimental session on the second day | ||
Other | Blood collection - myoglobin | 1 day after night with or without intervention. Before and after the match simulation and before the experimental session on the second day | ||
Other | Blood collection - brain-derived neurotrophic factor (BDNF) | 1 day after night with or without intervention. Before and after the match simulation and before the experimental session on the second day | ||
Other | Karolinska Sleep Diary (KSD) | 1 day after night with or without intervention. The morning of the session and the next day after the experimental session | ||
Primary | Countermovement jump | Vertical jump test performed by having an athlete quickly squat to a self-selected depth and then jump as high as possible. | 1 day after night with or without intervention | |
Primary | Sprint test (0-30m) | 1 day after night with or without intervention | ||
Primary | Zig Zag test | 1 day after night with or without intervention | ||
Primary | Zig Zag test with ball | 1 day after night with or without intervention | ||
Primary | Yo-Yo Intermittent endurance test level I | 1 day after night with or without intervention | ||
Primary | Flanker task | 1 day after night with or without intervention | ||
Secondary | Mood (POMS) | The POMS is a widely-applied measure for the assessment of an individual's mood. | 1 day after night with or without intervention. During each experimental session. Before sports performance protocol | |
Secondary | Pain (Pain scale) | A pain scale is a tool use to help assess a person's pain. Scale 0 (lack of pain) 10 (maximum pain) | 1 day after night with or without intervention. Immediately after the last performance exercise in experimental sessions | |
Secondary | Readiness-to-train questionnaire (RTT-Q) | Subjective reactions related to the level of motivation for effort | 1 day after night with or without intervention. During each experimental session. Before sports performance protocol | |
Secondary | Rating perceived exertion (RPE) | A subjective scale that assesses the severity of effort exerted. Includes a rating from 6 perceiving "no effort" to 20 perceiving "maximum effort." | 1 day after night with or without intervention. Immediately after the last performance exercise in experimental sessions | |
Secondary | Stress and recovery (SRSS) | The Short Recovery and Stress Scale (SRSS) measure the recovery-stress state of an athlete multidimensionally with eight items on emotional, mental, physical, and overall levels. | 1 day after night with or without intervention. In the morning, each experimental day and the day after |
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