Sleep Clinical Trial - Implications of Anesthetics on Sleep Consolidation

Status Terminated

Clinical Trial Summary

Sleep leads to consolidation of learning in humans, restoring memories that were forgotten over a waking day and protecting memories against future forgetting. Although theories of consolidation have linked sleep spindles seen on electroencephalography to consolidation due to their putative role in hippocampal transfer to the neocortex (Antony et al, 2019; Antony & Paller, 2017), spindles have not yet been linked to consolidation of perceptual learning or generalized learning. Prior research by a collaborator on this project has shown that sleep specifically aids in the consolidation of generalized perceptual learning of speech (Fenn, Nusbaum, & Margoliash, 2003). Subjects show a 10-point reduction in performance after a waking retention period, while no loss is found after a retention period containing sleep (Fenn et al., 2003). Various measurable activities in the brain are associated with memory consolidation during sleep. This project intends study the effect of dexmedetomidine on memory consolidation during sleep Hypothesis 1 The gain in perceptual learning after a 90 minute natural sleep nap will also occur after 90 minutes of a sufficient dose of IV dexmedetomidine to replicate sleep. This result would suggest that consolidation can occur under this anesthetic state of consciousness. Hypothesis 2 The number and quality of sleep spindles seen on EEG in subjects administered dexmedetomidine will correlate with this gain in perceptual learning. This result would suggest that biomimetic sleep spindles are sufficient for producing memory consolidation. Only those subjects capable of giving their own consent will be considered for this study. The study will enroll 20 healthy subjects for this study between the ages of 18 and 35. All volunteers will be fit and healthy, meeting the American Society of Anesthesiologists (ASA) physical status classification ASA 1 (normal healthy subjects) and ASA 2 (stable chronic condition) and of normal body habitus. Prior to the study enrollment, each volunteer will sign an informed consent form. A standard anesthetic medical history will be taken in addition to performing a focused standard pre-anesthetic physical examination in order to rule out active and chronic medical problems.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Sleep

Clinical Trial Details

NCT number	NCT04329091
Study type	Interventional
Source	University of Chicago
Contact
Status	Terminated
Phase	Phase 4
Start date	October 16, 2020
Completion date	December 20, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04044495` - Sleep, Rhythms and Risk of Alzheimer's Disease	N/A
Recruiting	`NCT06079853` - Nurse Suicide: Physiologic Sleep Health Promotion Trial	N/A
Completed	`NCT05017974` - Research on Improving Sleep During Pregnancy	N/A
Recruiting	`NCT05206747` - Ottawa Sunglasses at Night for Mania Study	N/A
Enrolling by invitation	`NCT04253054` - Chinese Multi-provincial Cohort Study-Beijing Project
Completed	`NCT04513743` - Ultra Long-Term Sleep Monitoring Using UNEEG™ Medical 24/7 EEG™ SubQ	N/A
Completed	`NCT03251274` - Bath Machine on Sleep Quality in Nursing Home	N/A
Completed	`NCT04102345` - Lavender vs Zolpidem Sleep Quality During Diagnostic PSG	Early Phase 1
Completed	`NCT03725943` - Comparison of Dreem to Clinical PSG for Sleep Monitoring in Healthy Adults	N/A
Active, not recruiting	`NCT05062161` - Sleep Duration and Blood Pressure During Sleep	N/A
Completed	`NCT04562181` - Consistency Evaluation of the qCON, qNOX Indices and Bispectral Index	N/A
Completed	`NCT05576844` - Ai Youmian (Love Better Sleep) for People Living With HIV	N/A
Completed	`NCT05102565` - A Dyadic Telehealth Program for Alzheimer's Patients/Caregivers	N/A
Enrolling by invitation	`NCT04688099` - Synovial Fluid Sleep Study
Recruiting	`NCT04171245` - Prescribing Laughter for Sleep and Wellbeing in UAE University Students	N/A
Completed	`NCT03758768` - The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms	N/A
Completed	`NCT03163498` - Evaluation of Sleep Pattern and Mood Profile in Hypertensive Patients
Completed	`NCT04093271` - Investigating the Efficacy of Rest-ZZZ Formula in Healthy Participants With Difficulty Falling Asleep or Staying a Sleep	Phase 1
Completed	`NCT03673397` - The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression	N/A
Completed	`NCT04120363` - Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations	Phase 4

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.