Clinical Trials Logo
  1. Home
  2. Skin Squamous Cell Carcinoma
  3. NCT03353077

Alpha Radiation Emitters Device for the Treatment of Squamous Cell Carcinoma (DaRT)

Skin Squamous Cell Carcinoma Clinical Trial

Official title:
A Safety and Effectiveness Study of Intratumoral Diffusing Alpha Radiation Emitters on Squamous Cell Carcinoma

Clinical Trial Summary

A unique approach for Skin Squamous Cell Carcinoma (SCC) treatment employing intratumoral diffusing alpha radiation emitter device

Clinical Trial Description

This will be a prospective study, assessing the safety and effectiveness of intratumoral alpha radiation mediated treatment with Alpha DaRT seeds for the treatment of Skin Squamous Cell Carcinoma (SCC) tumors. Treatment will be delivered through radioactive sources (Alpha DaRT seeds) inserted into the tumors in the skin. This approach combines the advantages of local intratumoral irradiation of the tumor, as used in conventional brachytherapy, with the power of the alpha radiation emitting atoms, that will be introduced in quantities considerably lower than radiation therapy already used in patients. Lesions with histopathological diagnosis of squamous cell carcinoma will be studied. Reduction in tumor size 30-45 days after DaRT insertion will be assessed. Safety will be assessed by the incidence, severity and frequency of all Adverse Events (AE). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03353077
Study type Interventional
Source Alpha Tau Medical LTD.
Contact
Status Completed
Phase N/A
Start date November 21, 2017
Completion date July 14, 2019
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT02978625 - Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Phase 2
Active, not recruiting NCT03944941 - Avelumab With or Without Cetuximab in Treating Patients With Advanced Skin Squamous Cell Cancer Phase 2
Recruiting NCT05269381 - Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors Phase 1
Completed NCT01807546 - Oral Rigosertib for Squamous Cell Carcinoma Phase 2
Active, not recruiting NCT04234113 - Study of SO-C101 and SO-C101 in Combination With Pembro in Adult Patients With Advanced/Metastatic Solid Tumors Phase 1
Active, not recruiting NCT02964559 - Pembrolizumab in Patients With Locally Advanced or Metastatic Skin Cancer Phase 2
Recruiting NCT03822988 - ACCEPTABILITY AND WRITING FREQUENCY OF ADVANCED DIRECTIVES IN ONCO-DERMATOLOGY PATIENTS
Recruiting NCT06223659 - EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers Phase 2
Active, not recruiting NCT00954226 - Phase Ib Study of Erlotinib Prior to Surgery in Patients With Head and Neck Cancer Phase 1
Completed NCT03108131 - Cobimetinib and Atezolizumab in Treating Participants With Advanced or Refractory Rare Tumors Phase 2