Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT06217627 |
Other study ID # |
S2021-cor001 |
Secondary ID |
|
Status |
Completed |
Phase |
Phase 1
|
First received |
|
Last updated |
|
Start date |
March 5, 2021 |
Est. completion date |
June 30, 2023 |
Study information
Verified date |
February 2024 |
Source |
COR clinic of Regenerative Medicine |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
This clinical trial aims to investigate the effect of umbilical cord explants (UC)-explants
and UC-mesenchymal stem cells (MSCs) secretome on skin rejuvenation, to provide future
reference or standard in the application of cell free-based therapy in skin aging.
Description:
This trial is a pilot clinical trial evaluating the effect of the secretions of umbilical
cord explants and mesenchymal stem cells on skin rejuvenation. Also the concentration of
selected growth factors was assessed in the secretome derived from UC-explants and UC-MSCs.
Healthy women participants, after their consent, received secretome injections in their
hands, face, and neck. Outcomes were assessed on the Hand Volume Rating Scale, Wrinkle
Severity Rating Scale, and through histologic examination of skin biopsy at two different
times: before treatment and after 12 months. A digital camera was used to obtain photographs
of hands, face, and Neck at each visit. These were assessed by a single-blinded
dermatologist. SPSS software version 26 (64-bit) was used for all analyses.
Participants provided written informed consent and were asked not to change their routine
skin care habits during the study.