Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Other |
The change of total cholesterol of blood |
Venous blood was sampled to measure total cholesterol |
Change from Baseline total cholesterol at 4 weeks |
|
Other |
The change of triglyceride of blood |
Venous blood was sampled to measure triglyceride |
Change from Baseline triglyceride at 4 weeks |
|
Other |
The change of SGOT of blood |
Venous blood was sampled to measure SGOT |
Change from Baseline SGOT at 4 weeks |
|
Other |
The change of SGPT of blood |
Venous blood was sampled to measure SGPT |
Change from Baseline SGPT at 4 weeks |
|
Other |
The change of BUN of blood |
Venous blood was sampled to measure BUN |
Change from Baseline BUN at 4 weeks |
|
Other |
The change of creatinine of blood |
Venous blood was sampled to measure creatinine |
Change from Baseline creatinine at 4 weeks |
|
Other |
The change of uric acid of blood |
Venous blood was sampled to measure uric acid |
Change from Baseline uric acid at 4 weeks |
|
Primary |
The change of skin wrinkles |
VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units |
Change from Baseline skin wrinkles at 4 weeks |
|
Primary |
The change of skin texture |
VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units |
Change from Baseline skin texture at 4 weeks |
|
Primary |
The change of skin collagen density |
DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units |
Change from Baseline skin collagen density at 4 weeks |
|
Primary |
The change of skin elasticity |
Soft Plus was utilized to measure skin elasticity. Units: arbitrary units |
Change from Baseline skin elasticity at 4 weeks |
|
Primary |
The change of MMP-1 of blood |
Venous blood was sampled to measure MMP-1 |
Change from Baseline MMP-1 at 4 weeks |
|
Primary |
The change of TIMP-1 of blood |
Venous blood was sampled to measure TIMP-1 |
Change from Baseline TIMP-1 at 4 weeks |
|
Secondary |
The change of skin melanin index |
Soft Plus was utilized to measure skin melanin index. Units: arbitrary units |
Change from Baseline skin melanin index at 4 weeks |
|
Secondary |
The change of skin L* value |
Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100 |
Change from Baseline L* value at 4 weeks |
|
Secondary |
The change of skin spots |
VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units |
Change from Baseline skin spots at 4 weeks |
|
Secondary |
The change of skin UV spots |
VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units |
Change from Baseline skin UV spots at 4 weeks |
|
Secondary |
The change of skin brown spots |
VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units |
Change from Baseline skin brown spots at 4 weeks |
|
Secondary |
The change of TNF-a of blood |
Venous blood was sampled to measure TNF-a |
Change from Baseline TNF-a at 4 weeks |
|
Secondary |
The change of IL-10 of blood |
Venous blood was sampled to measure IL-10 |
Change from Baseline IL-10 at 4 weeks |
|
Secondary |
The change of SOD-RBC of blood |
Venous blood was sampled to measure SOD-RBC |
Change from Baseline SOD-RBC at 4 weeks |
|
Secondary |
The change of f-thiols of blood |
Venous blood was sampled to measure f-thiols |
Change from Baseline f-thiols at 4 weeks |
|
Secondary |
The change of t-GSH of blood |
Venous blood was sampled to measure t-GSH |
Change from Baseline t-GSH at 4 weeks |
|
Secondary |
The change of GST-RBC of blood |
Venous blood was sampled to measure GST-RBC |
Change from Baseline GST-RBC at 4 weeks |
|
Secondary |
The change of MDA of blood |
Venous blood was sampled to measure MDA |
Change from Baseline MDA at 4 weeks |
|
Secondary |
The change of skin moisture |
Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 |
Change from Baseline skin moisture at 4 weeks |
|
Secondary |
The change of blood total antioxidant capacity (TAC) |
Venous blood was sampled to measure concentrations of TAC |
Change from Baseline TAC at 4 weeks |
|