Clinical Trials Logo

Sinusitis clinical trials

View clinical trials related to Sinusitis.

Filter by:
  • Terminated  
  • Page 1 ·  Next »

NCT ID: NCT05331222 Terminated - Chronic Rhinitis Clinical Trials

Proof-of-Concept Interventional Study With a Nasal Spray of JT-1 in Patients With Chronic Rhinitis or Chronic Sinusitis

Start date: September 30, 2022
Phase: N/A
Study type: Interventional

Proof-of-concept study with a novel nasal spray in chronic rhinitis or chronic sinusitis. The study will involve 25 patients completing the study for a per protocol analysis.

NCT ID: NCT05220293 Terminated - Clinical trials for Chronic Rhinosinusitis (Diagnosis)

Treatment of Eosinophilic Chronic Rhinosinusitis Utilizing Betamethasone Dipropionate Nasal Cream

OT-007
Start date: February 23, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open-label, single dose, pilot study, to assess the efficacy and safety of Betamethasone Dipropionate Nasal Cream 0.0644% (equivalent to 0.05% Betamethasone) for the treatment of eosinophilic Chronic Rhinosinusitis (eCRS).

NCT ID: NCT04783389 Terminated - Clinical trials for Chronic Rhinosinusitis With Nasal Polyps

A Study to Evaluate CBP-201, Rademikibart, in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps

Start date: June 16, 2021
Phase: Phase 2
Study type: Interventional

This study will evaluate the effect of CBP-201, rademikibart, in adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).

NCT ID: NCT04664803 Terminated - Acute Sinusitis Clinical Trials

Safety and Efficacy of Cefecin Tab. in Patients With Acute Sinusitis

CASIS
Start date: August 31, 2015
Phase: Phase 4
Study type: Interventional

This is a multi-center, double-blind, randomized, active controlled, parallel group phase 4 clinical trial to re-confirm the efficacy and safety of cefetamet pivoxil formulation in sinusitis patients

NCT ID: NCT04104594 Terminated - Nasal Polyps Clinical Trials

Olfaction and Inflammation in Chronic Rhinosinusitis With Nasal Polyps

OIPN
Start date: February 5, 2020
Phase: N/A
Study type: Interventional

Impaired olfaction is one of the major complaints of patients with nasosinus polyposis, with nasal obstruction. In case of failure of medical treatment for patients with polyposis nasosinusal, they may use endoscopic surgery nasosinusal. Before surgery, 73% are hyposmic or anosmic, compared to 43% after surgery. Persistence of hyposmia or anosmia despite the removal of polyps can be explained by mechanisms inflammatory in the mucous membrane of the olfactory cleft. In addition, studies in mice have shown a degeneration of primary olfactory neurons at the level of the olfactory mucosa in connection with directly with TNF alpha, a pro-inflammatory molecule.

NCT ID: NCT03822962 Terminated - Pain, Postoperative Clinical Trials

Pain Management Following Sinus Surgery

Start date: November 7, 2020
Phase: Early Phase 1
Study type: Interventional

This Study evaluates the effect of adding Non-steroidal anti-inflammatories (NSAIDs) to the post-operative pain management of sinus surgery patients and wether or not this addition reduces or eliminates the need for narcotic pain medications. Patients will be instructed to take an NSAID regimen after surgery and will be instructed to take narcotics only for breakthrough pain.

NCT ID: NCT03675022 Terminated - Sleep Apnea Clinical Trials

Effect of Dupilumab on Sleep Apnea in Patients With Rhinosinusitis

Start date: August 15, 2018
Phase: Early Phase 1
Study type: Interventional

Obstructive Sleep Apnea (OSA) is a common disorder with serious consequences that remains underrecognized, with >80% of OSA patients undiagnosed, and undertreated due to inadequate treatment options. The development of additional treatments for OSA, such as pharmacotherapy, are critically needed. The collaboration between Regeneron and Sanofi are funding this project. Regeneron will be providing the drug and the contract will be with Regeneron. Both companies are involved as it is a collaboration across the companies.

NCT ID: NCT03584737 Terminated - Sinusitis Bacterial Clinical Trials

Point-of-Care Immunoassay for Detection of Bacterial Sinusitis

Start date: November 12, 2021
Phase:
Study type: Observational

This study is conducted to evaluate the performance of a rapid, point-of-care in vitro diagnostic device (Sinu-Test®) for the qualitative detection of the three most common pathogens responsible for causing bacterial sinusitis.

NCT ID: NCT03534362 Terminated - Stent Clinical Trials

Propel Stent vs Kenalog-soaked Nasopore After Frontal Drill-out

Start date: April 13, 2018
Phase: N/A
Study type: Interventional

Surgery on the frontal sinus is done for patients who have sinus problems that do not respond to medications. It involves making an opening within the right and left frontal sinus of the nose to help it drain. For severe frontal sinus disease, the sinus is widely opened and the left and right sinuses become one large sinus. This is done with sharp instruments and rigid endoscopes placed through the nostrils. While the sinus heals after surgery, a stent or steroids or both may be used to try to help make sure that the opening does not close back up. Two current options for this are Propel stents and steroid-soaked Nasopore. Propel stents are FDA-approved. Nasopore and Kenalog injection are both FDA-approved, but their use together is part of the study and not specifically FDA-approved. A previous study shows that Propel stents are useful to reduce scarring in other frontal sinus procedures. We would like to know whether this is true in larger frontal sinus surgery where one common cavity is made and whether both steroid-containing stents are the same.

NCT ID: NCT03454607 Terminated - Sinusitis Clinical Trials

Foot Controlled Robotic Endoscope Enabled Robot FESS

Start date: January 4, 2018
Phase: N/A
Study type: Interventional

To evaluate the safety and feasibility of a Foot Controlled Robotic Endoscope Enabled Robot (FREE) in performing functional endoscopic sinus surgery to answer the two key questions: 1. Is the FREE robot feasible to use in patients for endoscopic sinus surgery? 2. Is the FREE robot safe to use in patients for endoscopic sinus surgery?