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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01483495
Other study ID # 20107521
Secondary ID
Status Completed
Phase
First received
Last updated
Start date December 2011
Est. completion date December 2011

Study information

Verified date October 2022
Source University of California, Irvine
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The brain is such a metabolically active organ that it consumes about 20% of oxygen burned every minute by an average adult even though it only contributes about 2% of the body weight. As a result, the brain produces a disproportionately high amount of CO2 every minute in comparison with the rest of the body.


Description:

The researcher can use Diffuse Optical Spectroscopy Imaging, cerebral non-invasive oximetry instrument, to determine cerebrovascular reactivity during surgery procedure. Specifically, the cerebral tissue O2 saturation can measure by Diffuse Optical Spectroscopy Imaging can use for cerebral blood flow in the evaluation of cerebrovascular reactivity. Adequate brain perfusion is critical not only to supply oxygen and nutrients but also to wash out metabolic end products including CO2. Blood flow depends on perfusion pressure and vascular bed resistance. It is well known that multiple physiological and pathological factors affect cerebral vasculature, and the resistance to blood flow. The cerebrovascular responsiveness to those factors determines how well the brain can maintain and adjust its perfusion.


Recruitment information / eligibility

Status Completed
Enrollment 78
Est. completion date December 2011
Est. primary completion date December 2011
Accepts healthy volunteers No
Gender All
Age group 20 Years and older
Eligibility Inclusion Criteria: 1. Male or Female 20 years of age and older 2. Female non-pregnant 3. Subject scheduled for elective surgery under general anesthesia with intubation. 4. Subject who is able to give informed consent. Exclusion Criteria: 1. Less than 20 years old of age 2. Pregnant woman 3. Subjects currently diagnosed with severe hypertension, myocardial ischemic disease, symptomatic valvular disease(s), symptomatic arrhythmia, uncompensated congestive heart failure, intracranial aneurysm.

Study Design


Intervention

Device:
Diffuse optical spectroscopy
Diffuse Optical Spectroscopy Imaging Cerebrovascular Reactivity

Locations

Country Name City State
United States UCI Beckman Laser Institute Irvine California

Sponsors (2)

Lead Sponsor Collaborator
University of California, Irvine Beckman Laser Institute University of California Irvine

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Brain blood flow Optical Imaging assess of Brain blood flow during surgical procedure 6 hours
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