Sickness Behavior Clinical Trial
Official title:
Inflammation Och hjärnfunktion - Huvudstudie
In this randomized double blind study, 52 healthy participants were injected with either 0.6 ng/kg body weight or placebo to test if changes in pain sensitivity is associated with change in neural activity using BOLD MR scanning.
52 healthy participants were included in this randomized double blind study. Participants
were injected once, and randomized to injection with with the active component or placebo.
Participants were recruited by advertising and screened through questionnaires and a health
examination by a physician. They were asked not to engage in strenuous physical activities,
sleep regular hours and refrain from alcohol the day before the experiment. If the
participants felt ill, e.g. coming down with a cold, they were instructed to call and were
rescheduled for a later appointment. C-reactive protein (CRP) was assessed to exclude
participants having an ongoing infection on the experimental day. Pregnancy was also an
exclusion criteria and a pregnancy test was administered for all female participants on
arrival. Pain sensitivity measures were tested at baseline and at peak inflammatory response
1-2 hours after injection. Both deep and cutaneous pain at threshold and suprathreshold
noxious levels were tested. Heat- and cold (cutaneous) pain sensitivity was assessed for
threshold stimuli and intense noxious stimuli, as well as pressure (deep) pain thresholds and
CPM (descending pain inhibition). These tests were conducted while the participants were in
the MR-scanner to investigate neural correlates to change in pain sensitivity. Subjects
filled out questionnaires at baseline, 90 minutes, 3.5 and 5 hours after injection.
The study and the procedures used in the study are described in detail here:
https://openarchive.ki.se/xmlui/bitstream/handle/10616/44650/Thesis_Bianka_Karshikoff.pdf?seq
uence=8&isAllowed=y
The following papers using data from this study is published:
Lindstedt F, Karshikoff B, Schalling M, Olgart Hoglund C, Ingvar M, Lekander M & Kosek E.
Serotonin-1A Receptor Polymorphism (rs6295) Associated with Thermal Pain Perception. PLOS
ONE. 2012;7(8):e43221. Epub 2012/09/07.
Karshikoff B, Jensen KB, Kosek E, Kalpouzos G, Soop A, Ingvar M, Olgart Höglund C, Lekander
M, Axelsson J. Why sickness hurts: A central mechanism for pain induced by peripheral
inflammation. Brain, Behavior, and Immunity 2016 Oct;57:38-46.
Lekander M, Karshikoff B, Johansson E, Soop A, Fransson P, Lundström J N, Andreasson A,
Ingvar M, Petrovic P, Axelsson J/Nilsonne G. Intrinsic functional connectivity of insular
cortex and symptoms of sickness during acute experimental inflammation. Brain, Behavior, and
Immunity 2016 Aug;56:34-41.
Andreasson A, Wicksell RK, Lodin K, Karshikoff B, Axelsson J, Lekander M. A Global Measure of
Sickness Behavior: Development of the Sickness Questionnaire (SicknessQ). Journal of Health
Psychology. 2016 Jul 24.
Karshikoff B, Lekander M, Soop A, Lindstedt F, Ingvar M Kosek E, Olgart Höglund C, & Axelsson
J. Modality and sex differences in pain sensitivity during human endotoxemia. Brain,
Behavior, and Immunity. 2015 May;46:35-43
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