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NCT06158945 Clinical Trial

The Role of Endothelin 1 as a Marker of Renal Impairment in Sickle Cell Disease

Sickle Cell Disease Clinical Trial

Official title:
The Role of Endothelin 1 as a Marker of Renal Impairment in Sickle Cell Disease

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06158945
Other study ID # soh_Med_23_10_01MS
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date October 24, 2023
Est. completion date October 23, 2024

Study information
Verified date November 2023
Source Sohag University
Contact Esraa A Quenawey, resident
Phone 01026841188
Email esraaanwar@med.sohag.edu.eg
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Sickle cell disease (SCD) refers to a group of hemoglobinopathies that include mutations in the gene encoding the beta subunit of hemoglobin. Within the umbrella of SCD, many subgroups exist, namely sickle cell anemia (SCA), hemoglobin SC disease (HbSC), and hemoglobin sickle-beta-thalassemia (beta-thalassemia positive or beta-thalassemia negative). Several other minor variants within the group of SCDs also, albeit not as common as the varieties mentioned above. It is essential to mention the sickle cell trait (HbAS), which carries a heterozygous mutation and seldom presents clinical signs or symptoms. Sickle cell anemia is the most common form of SCD

Recruitment information / eligibility
Status Recruiting
Enrollment 30
Est. completion date October 23, 2024
Est. primary completion date October 23, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 1 Year to 18 Years
Eligibility Inclusion Criteria: - The patients fulfilling all the following criteria will be included: - Patients with sickle cell disease in the age range of 1-18years. Exclusion Criteria: - Patients diagnosed to have coexistent renal disease before the study

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• urinary endothelin 1
assesment of endothelin 1 in urinary sample

Locations
Country Name City State
Egypt Sohag university Hospital Sohag

Sponsors (1)
Lead Sponsor Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

References & Publications (4)

Lonergan GJ, Cline DB, Abbondanzo SL. Sickle cell anemia. Radiographics. 2001 Jul-Aug;21(4):971-94. doi: 10.1148/radiographics.21.4.g01jl23971. — View Citation

Nath KA, Katusic ZS. Vasculature and kidney complications in sickle cell disease. J Am Soc Nephrol. 2012 May;23(5):781-4. doi: 10.1681/ASN.2011101019. Epub 2012 Mar 22. — View Citation

Platt OS. Sickle cell anemia as an inflammatory disease. J Clin Invest. 2000 Aug;106(3):337-8. doi: 10.1172/JCI10726. No abstract available. — View Citation

Williams TN, Thein SL. Sickle Cell Anemia and Its Phenotypes. Annu Rev Genomics Hum Genet. 2018 Aug 31;19:113-147. doi: 10.1146/annurev-genom-083117-021320. Epub 2018 Apr 11. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary renal affection in sickle cell patients assessment of urinary endothelin 1 as a marker of renal impairment in sickle cell patients 1 year
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