Study on Use of Omega-3 Fatty Acids to Improve Outcomes in Individuals

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

Sickle cell disease (SCD) is associated with significant morbidity and mortality. Pain and many adverse outcomes occurring in sickle cell disease are inflammatory driven. Recent data has shown that gut dysbiosis is present in individuals with sickle cell disease. Gut dysbiosis has been linked to inflammation in certain diseases. Omega -3-fatty acids (fish oil) has been shown to improve pain outcomes in individuals with sickle cell disease, but its acceptance is variable. The aim of this study is to determine if a plant-based omega-3-fatty acids will be more acceptable and also improve outcomes in individuals with sickle cell disease. Children aged 5-18 years will be randomized to receive a diet rich in omega-3-fatty acids versus a regular diet for 12 weeks after which there will be a cross over of arms after a 4-week wash out period. We will compare outcomes (including patient reported pain outcomes and improvement in inflammation markers) while on the omega-3 fatty acid rich diet. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05758766
Study type	Interventional
Source	University of Alabama at Birmingham
Contact	Dike
Phone	2056389918
Email	cdike@uabmc.edu
Status	Recruiting
Phase	N/A
Start date	August 30, 2023
Completion date	December 30, 2025

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Study on Use of Omega-3 Fatty Acids to Improve Outcomes in Individuals With Sickle Cell Disease

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms