Alternative Dosing And Prevention of Transfusions (ADAPT)

Status Recruiting

Clinical Trial Summary

ADAPT is a prospective cohort study at Jinja Regional Referral Hospital (JRRH) primarily to assess the effect of hydroxyurea on blood transfusion utilization and secondarily to determine the feasibility of PK-guided hydroxyurea dosing.

Clinical Trial Description

Hypothesis - There will be a 50% reduction in the rate of blood transfusions received during the hydroxyurea treatment period compared with the pre-treatment period. - A PK-guided starting dose will be generated for 80% of participants. - Participants on PK-guided hydroxyurea treatment will require 25% fewer blood transfusions during their first year of hydroxyurea than those on dose escalation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05662098
Study type	Interventional
Source	Children's Hospital Medical Center, Cincinnati
Contact	Russell Ware, MD, PhD
Phone	(513) 803-1108
Email	russell.ware@cchmc.org
Status	Recruiting
Phase	Early Phase 1
Start date	June 16, 2022
Completion date	December 31, 2027

View Details

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