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Safety of Single Doses of CSL889 in Adult Patients With Sickle Cell Disease

Sickle Cell Disease Clinical Trial

Official title:
A 2-Part, Phase 1, Multi-Center, Single-Dose, Open Label, Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of CSL889 in Adult Patients With Sickle Cell Disease

Clinical Trial Summary

This is a phase 1, first-in-human, multi-center, open-label, single dose cohort study to evaluate the safety and tolerability, pharmacokinetics (PK), exploratory pharmacodynamics (PD), and biomarkers of target engagement of CSL889 following single intravenous (IV) doses in subjects with sickle cell disease (SCD). The study involves sequential dose escalation of cohorts with between-group assessments of key safety and PK variables.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04285827
Study type Interventional
Source CSL Behring
Contact
Status Completed
Phase Phase 1
Start date May 20, 2021
Completion date July 24, 2023
View Details
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