Sickle Cell Disease Clinical Trial
Official title:
Academic Multicenter Prospective Observational Study of the Factors Responsible for Nephropathy in Patients With Sickle Cell Disease Followed by Belgium and the Nord-Pas -De- Calais Region and Creating a Biobank of Blood and Urine
The objective of the study is to refine our knowledge on the physiopathology of the symptoms
and the complications for the patients affected by a drepanocytic syndrome.
The establishment of risk factors and indicators of severity will allow to target better the
patients requiring an adequate strategy in order to prevent the installation of some
complications or to limit their worsening.
Some additional tubes will be taken during the usual control of blood test of the
drepanocytic patient. A sample of urine will be also asked. Tubes, after pre-treatment, will
be sent to Erasme hospital.
A series ob biological but also genetic parameters, both at asymptomatic patients and those
in aigüe phase of the disease, can be measured either immediately or a little time after the
prelevement.
In this way, we can study numerous domains linked to the physiopathology of the drepanocytose
(hémolyse, vaso-occlusion, rheology, factors modulators of the clinical expression). The
surplus of the collection could be used for other researchs. It's in this context that we
also wish to constitute a biobank of serum, plasma and urine for these drepanocytic patients
by surplus of taken material.
The study is realized within the framework of an academic collaboration between institutions.
The bank of takings will be located in the reference center of the pathologies of the Red
Blood Cell (laboratory of medical chemistry of the erasme hospital).
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