RHD Genotype Matching for Anti-D

Status Recruiting

Clinical Trial Summary

This is a pilot study to evaluate the feasibility and safety of providing RH genotype matched D+ Red Blood Cells (RBCs) to chronically transfused patients with sickle cell disease (SCD) who type D+ but have formed anti-D and are currently transfused with D- RBC (Red Blood Cell) units.

Clinical Trial Description

Red blood cell transfusion remains a critical therapy for patients with sickle cell disease (SCD). A major problem is the high rate of alloimmunization (antibody formation against transfused red cells) that occurs in patients with SCD. Recent studies performed by Investigators and others demonstrate RH genetic variants in patients and donors is a major risk factor leading to Rh alloimmunization. Anti-D formation in D+ patients occurs frequently, and once identified, providing D- cells for all subsequent transfusions can be challenging. These anti-D antibodies in D+ patients suggest exposure to different or variant D protein on donor cells. Investigators will test whether transfusion of patients with anti-D with RHD genotyped matched red cells is feasible, safe and can decrease D- donor unit demand. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04156906
Study type	Interventional
Source	Children's Hospital of Philadelphia
Contact	Stella Chou, MD
Phone	215-590-0947
Email	chous@chop.edu
Status	Recruiting
Phase	Early Phase 1
Start date	July 8, 2020
Completion date	July 2025

View Details

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