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A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease

Sickle Cell Disease Clinical Trial

Official title:
Proof-of-concept Study of Nicotinamide and Oral Tetrahydrouridine (THU) and Decitabine to Treat High Risk Sickle Cell Disease

Clinical Trial Summary

A randomized control trial in 20 subjects with sickle cell disease comparing oral THU-decitabine to nicotinamide and in combination (THU, decitabine and nicotinamide).

Clinical Trial Description

A randomized control trial comparing oral THU-decitabine to nicotinamide (1:1 randomization), and then comparing the effects of the combination of nicotinamide with THU-decitabine vs either treatment alone. Treatment with each agent alone is for 12 weeks followed by the combination for a further 12 weeks. Patients have the option to enter an extension phase of combination treatment for an additional 24 weeks (total of 48 weeks) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04055818
Study type Interventional
Source EpiDestiny, Inc.
Contact Lani Krauz
Phone 312-413-0242
Email LIgnacio@UIC.EDU
Status Recruiting
Phase Phase 1
Start date January 24, 2020
Completion date April 5, 2024
View Details
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