Stem Cell Transplant in Patients With Severe Sickle Cell Disease

Status Terminated

Clinical Trial Summary

This is a prospective pilot study of matched-related donor allogeneic stem cell transplantation in adults with severe sickle cell disease using a matched-sibling PBSC graft with a non-myeloablative conditioning regimen (Alemtuzumab).

Clinical Trial Description

Stem cell transplantation recipients will be given Alemtuzumab, which is a non-myeloablative pre-transplant conditioning regimen. This non-myeloablative therapy uses doses of chemotherapy and radiation to weaken (but not destroy) the patients bone marrow and immune system, while still allowing their body to accept the donor's stem cells. Alemtuzumab will be given 7 days prior to stem cell infusion at 0.03 mg/kg IV, 6 days prior to stem cell infusion at 0.1 mg/kg IV, and 5 thru 3 days prior to stem cell infusion at 0.3 mg/kg IV. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03421756
Study type	Interventional
Source	University of Pittsburgh
Contact
Status	Terminated
Phase	Early Phase 1
Start date	March 29, 2018
Completion date	May 15, 2022

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