Sickle Cell Disease Clinical Trial
Official title:
Cerebrovascular Reserve Measurements in Sickle Cell Disease: an MRI Study
The primary aim of this study is to evaluate MRI-based cerebrovascular reserve (CVR)
measurements in adult patients with Sickle Cell Disease (SCD).
The primary objective is to assess whether there is a correlation between CVR and silent
cerebral infarcts (SCIs).
CVR is hypothesized to be impaired in SCD patients and could account for the white matter
hyperintensities seen on MRI in these patients. Cerebral blood flow (CBF) alone is not
sufficient to provide insight into the hemodynamic status of the brain. CVR allows us to
gain insight into the capacity of the cerebrovasculature to respond to increased CBF.
Vasculopathy is common in SCD and the caliber of the vessels can be assessed with 4D Flow
MRI in response to actue and chronic changes in the velocity and wall shear stress on the
intracranial arteries in the Circle of Willis.
This study will be performed as a single center, patient-control, cross-sectional,
observational study in patients with steady-state SCD and controls. The investigators expect
that patients with impaired CVR will have a greater number and/or volume of SCIs.
;
Observational Model: Case Control, Time Perspective: Cross-Sectional
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