Screening Patients With Sickle Cell Disease for Kidney Damage

Status Completed

Clinical Trial Summary

This study aims to study the temporal course of sickle nephropathy and assess novel biomarkers that can predict patients prone to nephropathy.

Clinical Trial Description

Sickle cell disease causes kidney damage that gets worse with increasing age, leading to chronic kidney disease and kidney failure in nearly one third of patients with sickle cell disease. Some patients develop kidney damage at a young age and others show mild kidney damage at older ages. We do not know the natural progression of kidney damage in sickle cell disease patients, nor do we know who is more prone to develop severe kidney damage. Therefore, currently, there are no preventative measures or treatments for sickle cell related kidney disease. The purpose of this research study is to collect data that will help in assessing the progression of kidney damage in sickle cell disease, develop novel urine and blood tests that can predict kidney damage early, and developing treatment ideas for intervention and prevention of kidney damage that eventually leads to kidney failure. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02239016
Study type	Observational
Source	Children's Hospital Medical Center, Cincinnati
Contact
Status	Completed
Phase
Start date	April 2009
Completion date	July 29, 2020

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