Sickle Cell Disease Clinical Trial
— VOLCADREPOfficial title:
Evaluation of the Lung Capillary Blood Volume in Children With Sickle Cell Disease
Verified date | July 2012 |
Source | Assistance Publique - Hôpitaux de Paris |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Sickle cell disease (SCD) is the most common inherited disease of the world affecting African and Caribbean populations. SCD is caused by the homozygous inheritance of the gene for sickle hemoglobin (HbS). Most patients with SCD develop abnormal pulmonary function characterized by airway obstruction, restrictive lung disease, abnormal diffusing capacity, hypoxemia and pulmonary hypertension In healthy subjects, lung capillary blood volume (Qc) and membrane diffusing capacity (Dm) can be accurately measured by the nitric oxide-carbon monoxide (NO-CO) method. We propose to study, for the first time, lung capillary blood volume and alveolar membrane diffusing capacity, using the NO-CO method, in children with SCD aged of at least 6 years Early determination of lung function and pulmonary circulation in children with SCD is very important, not only for the understanding of physiopathologic mechanisms of the disease but also for a better therapeutic management of these children.
Status | Completed |
Enrollment | 120 |
Est. completion date | February 2012 |
Est. primary completion date | February 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 6 Years to 18 Years |
Eligibility | Inclusion Criteria: - Children between 6 and 18 years - Sickle cell disease( SS,SC, SBETA O, SDpunjab) and control without sickle cell disease - Social insurance - Signed informed consent Exclusion Criteria: - Respiratory disease other tha asthma - Cardiac disease - Encephalopathy - G6PD deficiency - Consent not signed |
Country | Name | City | State |
---|---|---|---|
France | Hopital Robert DEBRE | Paris |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris |
France,
Bokov P, Boizeau P, Pautrat J, Missud F, Ba A, Haouari Z, Denjean A, Delclaux C, Benkerrou M. Altered pulmonary capillary blood volume in childhood sickle cell disease. Eur Respir J. 2020 Dec 10;56(6):2000379. doi: 10.1183/13993003.00379-2020. Print 2020 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Study of lung capillary blood volume and alveolar membrane diffusing capacity using NO-CO method | The day of the measure | ||
Secondary | Respiratory physiopathology's study in sickle cell disease | At the induction of the study | ||
Secondary | Valid alveolar membrane diffusing capacity using NO-CO in children with or without sickle cell disease | At the induction of the study | ||
Secondary | Purpose respiratory function follow up in sickle cell disease child | At the induction of the study | ||
Secondary | Find relationship between these vascular abnormalities and NO metabolism | At the induction of the study |
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