Sickle Cell Disease Clinical Trial
Official title:
Systematic Evaluation of Sleep Respiratory Disorders During Sleep in Children With Sickle Cell Disease
In Sickle cell disease children, sleep respiratory abnormalities are risk factors for
vaso-occlusive complications, as well as cerebral vasculopathy.
A 18 months follow-up children with sickle cell disease evaluating sleep respiratory problems
frequency and etiology, as well as their influence on sickle cell disease complications.
- Inclusion visit with physical examination. A 2.9 ml blood sample will be necessary, if
not done within the framework of care within 6 months for: CBC (Cell Blood Count),
reticulocytes counts (1.2 ml of blood), liver enzymes, electrolytes, urea, creatininemia
(1,2 ml of blood) and fetal hemoglobin (0.5 ml of blood). - A complete standardized
examination including nasopharynx endoscopy, if not yet done in usual care, to
identified upper airway obstruction
- A standardized pneumology evaluation to identified obstructive lung symptomatology
- An ambulatory polysomnography will be performed within days following inclusion, during
sleep and will allow electroencephalogram recording, oculomotricity, muscles (mentalis
muscles and tibialis anterior) movements, electrocardiogram and respiratory activity
recording.
The steering committee will classify the children in three populations based on their exam
results:
- Group 1: no abnormality in polysomnography
- Group 2: obstructive sleep-related disorder
- Group 3: isolated sleep hypoxemia for group3, patients will have a new ambulatory
polysomnography.
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