Sickle Cell Anemia Clinical Trial
OBJECTIVES:
I. Compare the efficacy of hydroxyurea with or without clotrimazole in terms of limiting the
severity of anemia and the rate of hemolysis in patients with sickle cell anemia.
PROTOCOL OUTLINE: This is a randomized study. Patients are randomized to one of two
treatment arms.
Arm I: Patients receive oral hydroxyurea and oral clotrimazole daily for 12 months.
Arm II: Patients receive oral hydroxyurea daily for 12 months. Patients are followed at 6
weeks.
Completion date provided represents the completion date of the grant per OOPD records
;
Allocation: Randomized, Primary Purpose: Treatment
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