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Neutrophil Extracellular Traps and Sickle Cell Disease

Sickle Cell Anemia Clinical Trial

Clinical Trial Summary

NETs formation in vaso-occlusive events in sickle cell disease and the role of hydroxyurea treatment.The study hypothesis is that NETs formation by neutrophils has a role in the induction of vaso occlusive disease in blood vessels. It is possible that high leukocyte count in children with sickle cell anemia is a bad prognostic sign due to NETs formation supporting occlusion of peripheral and central blood vessels.Hydroxyurea treatment might prevent vaso occlusive syndrome not only by increasing HbF but also by decreasing neutrophil count and inhibiting NETs formation.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02004808
Study type Observational
Source Tel-Aviv Sourasky Medical Center
Contact Ronit Elhasid, MD
Phone 972524266464
Email ronite@tasmc.health.gov.il
Status Not yet recruiting
Phase N/A
Start date February 2014
Completion date December 2019
View Details
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