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Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test — OFTaPLR  

Shock, Septic Clinical Trial

Official title:
Optimization of Fluid Therapy by a Passive Leg Raising Test in Patients With Septic Shock in the ICU

Clinical Trial Summary

A randomized controlled clinical trial to evaluate whether a passive leg raising test to guide fluid therapy of patients with septic shock can reduce fluid balance and weight gain. Patients will be treated according to an algorithm in which the indexed stroke volume (stroke volume related to body surface area) and mean arterial pressure will guide the timing and amount of fluid and the use of inotropic and vasoactive support. Patients will be randomized to either an intervention group in which a passive leg raising test will be made prior to any decision for fluid administration or to a control group where this test is not performed and fluid administration is carried out according to standard of care at the department.

Hypothesis: A passive leg raising test, will reduce weight gain by day 3 by 30%.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02301585
Study type Interventional
Source Karolinska Institutet
Contact
Status Terminated
Phase N/A
Start date February 2014
Completion date February 2016
View Details
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