The Effects of Sevoflurane and Desflurane on QT Interval Measured With Cardiac Electrophysiological Balance Index

Sevoflurane Clinical Trial

Official title:

A Prospective Randomized Comparison of the Effects of Sevoflurane and Desflurane Anesthesia on QT Interval Measured With Cardiac Electrophysiological Balance Index

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05225779
• Other study ID #: E1-21-2256
• Status: Not yet recruiting
• Phase: N/A
• Start date: February 2022
• Est. completion date: July 2022

Study information

• Verified date: February 2022
• Source: Ankara City Hospital Bilkent
• Contact: betül güven aytaç
• Phone: +905073578351
• Email: drbguven[@]hotmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The primary aim of this study is to compare the effects of sevoflurane and desflurane on the QT interval. The secondary aim of this study is to compare the effects of drugs used in the induction and maintenance of anesthesia on the QT interval by calculating the Bazzet formula and iCEB.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 120
• Est. completion date: July 2022
• Est. primary completion date: May 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. ASA I-II-III risk group

2. the operation time is longer than 1 hour in the Urology department.

Exclusion Criteria:

1. bundle branch block in preoperative ECG,

2. Non-sinus heart rhythm,

3. QT length in preoperative ECG,

4. using drugs that cause known QT prolongation ( beta-blocker drugs using will be included),

5. development of malignant arrhythmia that will disrupt hemodynamics in the intraoperative period,

6. patients with electrolyte disorders,

7. patient refusal -

Related Conditions & MeSH terms

• Desflurane
• QT Interval
• Sevoflurane

Intervention

Diagnostic Test:
• 12- derivation Electrocardiography
6 precordial and 4 extremity electrodes will be placed at appropriate anatomical points and a total of 6 12-lead ECGs will be taken at different anesthesia depths before anesthesia induction and throughout the operation.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Ankara City Hospital Bilkent

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	QTc T0	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ vRR).	Baseline, preoperative
Primary	QTc T1	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ vRR).	During surgery (at the time of the anesthesia induction)
Primary	QTc T2	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ vRR).When the mac value reaches 0,6, it will be calculated from the ECG.	During surgery (at the time of MAC reached 0,6)
Primary	QTc T3	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ vRR).When the mac value reaches 1, it will be calculated from the ECG.	During surgery (at the time of MAC reached1)
Primary	QTc T4	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ vRR).When the mac value reaches 1,3 , it will be calculated from the ECG.	During surgery (at the time of MAC reached 1,3)
Primary	QTc T5	QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ vRR).When the mac value reduces 0,3, it will be calculated from the ECG.	During surgery (at the time of MAC reduced 0,3)
Primary	iCEB T0	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS)	Baseline, preoperative
Primary	iCEB T1	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS)	During surgery (at the time of the anesthesia induction)
Primary	iCEB T2	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 0,6, it will be calculated from the ECG.	During surgery (at the time of MAC reached 0,6)
Primary	iCEB T3	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1, it will be calculated from the ECG.	During surgery (at the time of MAC reached 1)
Primary	iCEB T4	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1,3, it will be calculated from the ECG.	During surgery (at the time of MAC reached 1,3)
Primary	iCEB T5	Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) when the mac value reduces 0,3, it will be calculated from the ECG.	During surgery (at the time of MAC reduced 0,3)