Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Sepsis

Severe Sepsis With Septic Shock Clinical Trial

Official title: Randomized Control Trial to Assessed the Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Severe Sepsis

Status Completed

Clinical Trial Summary

Sepsis is a clinical syndrome which infection trigger systemic inflammatory response. Uncontrolled inflammatory process leads to multiple organ dysfunction and cause early mortality in severe sepsis. Unfractionated heparin is an anticoagulant that widely used either for DVT prophylaxis or treatment of disseminated intravascular coagulation. Heparin also have an anti-inflammatory effect through downregulates nuclear factor kappa B and tumor necrosis factor alpha.

Aim of this study is to determine effects of low dose unfractionated heparin treatment on inflammation in severe sepsis patient.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Inflammation
• Sepsis
• Severe Sepsis With Septic Shock
• Severe Sepsis Without Septic Shock
• Shock
• Shock, Septic
• Toxemia

• NCT number: NCT02135770
• Study type: Interventional
• Source: Indonesia University
• Status: Completed
• Phase: Phase 3
• Start date: January 2013
• Completion date: June 2014