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Gut Hormones as Mediators of Different Weight Loss Responses After Roux-en-Y Gastric Bypass

Severe Obesity Clinical Trial

Clinical Trial Summary

After gastric bypass, 10-20% of patients will obtain a suboptimal weight loss, often defined as <50% of the excess body weight. Exaggerated meal related secretion of gut hormones seem important for appetite reduction and subsequent weight loss after gastric bypass, however it is not clear whether different gut hormone responses are responsible for different postoperative weight loss responses. The purpose of the study is to investigate gut hormone secretion, vagal integrity and the effect of octreotide on ad libitum food intake in patients with suboptimal weight loss after gastric bypass and compare results to a matched group of gastric bypass operated patients with high postoperative weight loss but similar age, sex and preoperative BMI.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02374632
Study type Interventional
Source Hvidovre University Hospital
Contact
Status Active, not recruiting
Phase Phase 4
Start date October 2014
Completion date June 2017
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