Septic Shock Clinical Trial
Official title:
Time to Lose the Weight? Comparison of Weight-based and Non-weight-based Vasopressors for Septic Shock
Verified date | November 2021 |
Source | Methodist Health System |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
At present, there is conflicting evidence regarding outcomes in patients with septic shock receiving weight-based vasopressor (WBVP) versus non-weight-based vasopressor (NWBVP) dosing strategies. At MCMC, a weight-based strategy is in place whereas MDMC, MMMC and MRMC currently utilize a non-weight-based dosing strategy. Obese patients (BMI > 30) receiving either strategy may potentially be receiving substantially more or less vasopressor exposure compared to their non-obese (BMI < 30) counterparts. Determining total vasopressor exposure and assessing clinical outcomes would benefit our institution and others by providing optimal vasopressor dosing strategies in obese and non-obese patients. There is a difference in clinical outcomes between patients receiving weight-based and non-weight-based vasopressor dosing strategies. There is a difference in total vasopressor exposure between obese and non-obese patients utilizing WBVP and NWBVP strategies.
Status | Completed |
Enrollment | 945 |
Est. completion date | June 22, 2020 |
Est. primary completion date | June 22, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - ICU admission - Medical admission type - Received NE, epinephrine (EPI), phenylephrine (PE), or dopamine (DA) for septic shock - Received NE/EPI/PE/DA for > 24 hours - Age = 18 years Exclusion Criteria: - Non-sepsis indication for vasopressors - Surgical or trauma admission type - ICU length of stay < 24 hours - Pregnant |
Country | Name | City | State |
---|---|---|---|
United States | Methodist Dallas Medical Center | Dallas | Texas |
Lead Sponsor | Collaborator |
---|---|
Methodist Health System |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Efficacy: Total 48-hour vasopressor exposure | Total 48-hour vasopressor exposure (norepinephrine (NE) equivalents, mg) | 4/1/2017-8/31/2019 | |
Primary | Safety: Composite of in-hospital mortality, vasopressor-associated adverse events | Composite of in-hospital mortality, vasopressor-associated adverse events (arrhythmia, thrombosis) | 4/1/2017-8/31/2019 | |
Secondary | Efficacy: Total number of vasoactive agents required to maintain mean arterial pressure | Total number of vasoactive agents required to maintain mean arterial pressure (MAP) > 65 mmHg, time to hemodynamic stability, use of angiotensin II or vasopressin | 4/1/2017-8/31/2019 | |
Secondary | Safety: in-hospital mortality, vasopressor-associated adverse events | in-hospital mortality, vasopressor-associated adverse events (arrhythmia, thrombosis) | 4/1/2017-8/31/2019 |
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