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Clinical Trial Summary

Several data emphasize the relation between tachycardia (>90/min) and high mortality during septic shock. The investigators previously demonstrated the high mortality associated with hypercontractility, tachycardia and the presence of a left ventricular obstruction. A severe hypovolemia, a hyper adrenergic stimulation or a severe vasoplegia can all explain this relation between tachycardia, hypercontractility and the mortality during septic shock. Landiolol is another short-term acting beta-blocker with a half-life of 4 minutes without any beta 2 activity or membrane stabilizing effect. The landiolol has been used in critically ill patients to control supraventricular tachycardia but not in this context of tachycardia and septic shock. The investigators hypothesize that landiolol by reducing the heart rate may improve the survival of patients treated for a septic shock and presenting with an hypercontractility state.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04748796
Study type Interventional
Source Centre Hospitalier Universitaire, Amiens
Contact Slama Michel, Pr
Phone 03 22 08 78 41
Email slama.michel@chu-amiens.fr
Status Recruiting
Phase N/A
Start date February 1, 2021
Completion date March 2024

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