Sepsis Clinical Trial
Official title:
Central Venous Catheter Colonisation: Prevalence and Associated Factors Among Critically Ill Patients Admitted to Ugandan Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk
factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm
formation along the catheter insertion tract. This study set out to determine the prevalence
and associated factors for central venous catheter colonisation among critically ill patient.
No data exists in this clinical setting addressing this topic.
Methods: The study population included 100 participants with central venous catheters in situ
for at least 24 hours. Catheter tip (distal 5-cm segment) and blood cultures (10mls
peripheral blood) were obtained at the time of catheter removal.
Introduction : Central venous catheter (CVC) insertion technique and time spent in situ
(dwell period) are major risk factors for CVC colonisation among patients admitted to
intensive care units (ICU) worldwide. Normal skin flora colonizes CVCs early in their dwell
period (< 7-10 days) causing variable occurrence of infections in all categories of patients.
Uganda has no data on CVC colonisation and with increasing use there is concern of CVC
colonisation and its consequences. This study was done to determine the prevalence and
associated factors of CVC colonization among patients in general ICUs.
Methodology: This was prospective cohort study. Critically ill patients with CVCs in situ
from four general ICUs were consecutively enrolled into the study. Data on socio-demographic,
clinical characteristics (diagnosis, comorbidities) and CVC insertion (site, technique,
experience) was collected using a standardised questionnaire until a sample size of 100 was
achieved. At the time of CVC removal, the CVC tip (distal 5cm segment) was aseptically
obtained and cultured for microorganisms using the semi-quantitative method. A blood culture
sample (10mls) was also collected from a peripheral site at the same time. Data was double
entered into EPIDATA version 3.1.5 and exported to STATA version 12.0 for analysis.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT05095324 -
The Biomarker Prediction Model of Septic Risk in Infected Patients
|
||
| Completed |
NCT02714595 -
Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens
|
Phase 3 | |
| Completed |
NCT03644030 -
Phase Angle, Lean Body Mass Index and Tissue Edema and Immediate Outcome of Cardiac Surgery Patients
|
||
| Completed |
NCT02867267 -
The Efficacy and Safety of Ta1 for Sepsis
|
Phase 3 | |
| Completed |
NCT04804306 -
Sepsis Post Market Clinical Utility Simple Endpoint Study - HUMC
|
||
| Recruiting |
NCT05578196 -
Fecal Microbial Transplantation in Critically Ill Patients With Severe Infections.
|
N/A | |
| Terminated |
NCT04117568 -
The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients
|
||
| Completed |
NCT03550794 -
Thiamine as a Renal Protective Agent in Septic Shock
|
Phase 2 | |
| Completed |
NCT04332861 -
Evaluation of Infection in Obstructing Urolithiasis
|
||
| Completed |
NCT04227652 -
Control of Fever in Septic Patients
|
N/A | |
| Enrolling by invitation |
NCT05052203 -
Researching the Effects of Sepsis on Quality Of Life, Vitality, Epigenome and Gene Expression During RecoverY From Sepsis
|
||
| Terminated |
NCT03335124 -
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock
|
Phase 4 | |
| Recruiting |
NCT04005001 -
Machine Learning Sepsis Alert Notification Using Clinical Data
|
Phase 2 | |
| Completed |
NCT03258684 -
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock
|
N/A | |
| Recruiting |
NCT05217836 -
Iron Metabolism Disorders in Patients With Sepsis or Septic Shock.
|
||
| Completed |
NCT05018546 -
Safety and Efficacy of Different Irrigation System in Retrograde Intrarenal Surgery
|
N/A | |
| Completed |
NCT03295825 -
Heparin Binding Protein in Early Sepsis Diagnosis
|
N/A | |
| Not yet recruiting |
NCT06045130 -
PUFAs in Preterm Infants
|
||
| Not yet recruiting |
NCT05361135 -
18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia
|
N/A | |
| Not yet recruiting |
NCT05443854 -
Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill Neutropenic Patients With Sepsis: (Combination-Lock01)
|
Phase 3 |