Sepsis Clinical Trial
Official title:
Paracetamol-induced Liver Toxicity in Septic Patients
The investigators will examine the toxicity of therapeutic doses of paracetamol in patients in severe sepsis. Patients with fever and severe sepsis will be randomized to receive paracetamol or dypirone. The investigators will monitor blood glutathione and liver enzymes to look for potential toxicity.
Paracetamol is metabolized in liver using the glutathione system. This detoxification system
is depressed during severe illness such as sepsis, trauma etc. The study will examine the
toxicity of therapeutic doses of paracetamol in patients in severe sepsis. We believe that
during sepsis, paracetamol metabolites are not fully detoxified and therefore are toxic to
the patient.
Patients with fever and severe sepsis will be randomized to receive paracetamol or dypirone.
The investigators will monitor blood glutathione (as a surrogate marker for liver
glutathione), liver enzymes and various clinical data (such as length of hospitalization) to
look for a potential toxicity.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label
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