Sepsis Clinical Trial
Official title:
Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care in Turkey
In this observational study, it is aimed to investigate the mortality and morbidity rates of hospital-acquired blood stream infections that are treated in intensive care units (ICU). The effects of properties of the micro-organism such as type and antimicrobial resistance on the infection and its outcomes will be mainly explored. In addition, the impact of antibiotic options and other treatment modalities on survival of patients will be investigated. Twenty-seven different ICUs from Turkey will be included in this study.
Blood stream infection (BSI) is defined as the identification of a culprit pathogen in the
blood culture sample of a participant. As such, and once contaminants are excluded, BSI is
the only cause of sepsis where the presence of an infection and the pathogen are known with
certainty. This makes BSI the perfect model of infection to study the effects of the
micro-organism on the participant, and the effects of the antibiotics and other treatments on
survival. There is an increasing trend in antimicrobial resistance rates among microorganisms
that are associated with nosocomial infections treated in ICU. However, infectious diseases
physicians from Turkey do not know contemporary epidemiological data of hospital-acquired BSI
treated in ICU in Turkey.
This study 'Epidemiology and Determinants of Outcomes of Hospital-Acquired Blood Stream
Infections in the Intensive Care in Turkey' is a multi-center prospective observational
cohort study that will include patients with hospital-acquired blood stream infections
(HA-BSI) treated in ICUs in Turkey. This study will present unknown current epidemiology of
HA-BSI in Turkey. Furthermore, It will provide very important data about 28-day mortality
rates of HA-BSI treated in ICU. The primary outcomes of this study can be accounted as
following: (i)determinants of outcomes of HA-BSI, (ii) the effects of the source of infection
on outcomes, (iii) the effects of microorganism on these outcomes, (iv) the effects of
antimicrobial therapy and of source control on investigated outcomes. In this study,
participant specific and organizational factors will be explored and the determinants of
management of HA-BSI in ICUs will be described.
There will be no intervention in this study. The data of participants will be obtained from
hospital database and recorded into electronic case report forms anonymously.
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