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The Membrane Adsorbing OXiris Filter in Septic Patients With AKI — MOSAKI  

Sepsis Clinical Trial

Official title:
The OXIRIS Filter in Septic Shock : the Adsorption of Endotoxin and Cytokines Improves the Haemodynamic , the Renal Function , and the Metabolic Response

Clinical Trial Summary

Patients with Sepsis / Septic Shock and AKI are submitted to Continuous Renal Replacement Therapy with the oXiris filter . The pro- inflammatory mediators , the endotoxin , interleukin 10 , the main cardiorespiratory indices and renal parameters are evaluated at the entry of the study and at the end of the treatment.

Clinical Trial Description

Patients with a diagnosis of sepsis or septic shock Gram + , Gram - and acute renal failure All patients are submitted to Continuous Renal Replacement Therapy with the treated heparin-coated membrane (oXiris;Baxter );

- Citrate Anticoagulation or Heparin with thromboelasthograpy monitoring .

- Hemodynamic monitoring with dynamic parameters ( Cardiac Index ,Stroke Volume Variation , Pulse Pressure Variation ) and Echocardiography

- Indirect Calorimetry ( before Continuous Renal Replacement Therapy and after 1 hour stopping Continuous Renal Replacement Therapy )

- Laboratory: white blood cell, creatinine, procalcitonin, Interleukin -6, Interleukin -10, Endotoxin , Lactate, diuresis, tromboelastography (post filter and arterial sample ) and dosage of Plasminogen Activator Inhibitor -1 at the same sites. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03914586
Study type Observational
Source University of Rome Tor Vergata
Contact
Status Recruiting
Phase
Start date January 10, 2019
Completion date July 30, 2020
View Details
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