Seizure Prophylaxis in Aneurysm Repair

Status Terminated

Clinical Trial Summary

Seizures are a potential complication of surgical repair of intracranial aneurysms. In order to prevent seizures, many surgeons administer prophylactic anti-epileptic medication during the intra-operative and post-operative period, however, such practice is not supported by clinical data. Retrospective review found the incidence of postoperative seizures was higher in those who received anti-epileptics versus those who did not. The goal is to examine the utility of levetiracetam (Keppra) for seizure prophylaxis in patients undergoing surgical repair of unruptured intracranial aneurysms.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01974700
Study type	Interventional
Source	Indiana University
Contact
Status	Terminated
Phase	Phase 4
Start date	July 2013
Completion date	February 2016

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT02850913` - Doxycycline for the Treatment of Nodding Syndrome	Phase 2
Recruiting	`NCT04076449` - Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Not yet recruiting	`NCT06045676` - Electrocardiographic Changes Among Epileptic and Non Epileptic Seizures in Children at Sohag University Hospital
Completed	`NCT03722212` - Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test	N/A
Not yet recruiting	`NCT05649891` - Checklists Resuscitation Emergency Department	N/A
Completed	`NCT02897856` - Efficacy and Safety of Intramuscular Midazolam Compared to Buccal Midazolam in Pediatric Seizures	Phase 4
Completed	`NCT01236001` - Belgian Drug-utilization Study to Evaluate the Use of VIMPAT® as Adjunctive Treatment of Partial Onset Seizures in Subjects Aged 16 and Older	N/A
Completed	`NCT01239212` - Dosing of Levetiracetam (Keppra) in Neonates	Phase 1/Phase 2
Completed	`NCT01703468` - Crossover Bioequivalence Study of Oxcarbazepine 600 mg Suspension Under Fed Conditions	Phase 1
Completed	`NCT01702623` - Crossover Bioequivalence Study of Oxcarbazepine 600 mg Suspension Under Fasted Conditions	Phase 1
Recruiting	`NCT02216500` - Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy	N/A
Completed	`NCT00236717` - A Study of the Effectiveness and Safety of Topiramate Compared With a Standard Therapy in Patients Newly Diagnosed With Epilepsy	Phase 3
Terminated	`NCT03954314` - DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery	Phase 3
Completed	`NCT05103735` - Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity
Terminated	`NCT03790436` - Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet	N/A
Completed	`NCT06451289` - Study on Optic Nerve Sheath Diameter Measurements in Prolonged Pediatric Seizures
Recruiting	`NCT02552511` - Epidemiology Study on Neonatal Seizure
Recruiting	`NCT05339126` - RNS System LGS Feasibility Study	Phase 2
Active, not recruiting	`NCT04595786` - The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection	N/A
Recruiting	`NCT04770337` - Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy	N/A