Secondary Hyperparathyroidism Clinical Trial
Official title:
A Prospective, Randomized Trial to Compare Subtotal Parathyroidectomy Versus Cinacalcet in the Treatment of Persistent Secondary Hyperparathyroidism Post Renal Transplantation
The hypothesis of this study is that subtotal parathyroidectomy using minimally invasive surgery is superior to cinacalcet for the treatment of persistent secondary hyperparathyroidism (HPT) post renal transplant, with minimal morbidity and significantly reduces the cost of treatment post transplant.
Persistent hyperparathyroidism (HPT) with hypercalcemia is prevalent after transplant
(affects up to 25% of patients) and negatively affects graft and patient outcome. The
subtotal parathyroidectomy is the standard treatment, although currently has been replaced
by the calcimimetic cinacalcet. Several studies guarantee that cinacalcet is effective in
controlling hypercalcemia derived of persistent HPT after renal transplantation. However,
maintenance treatment is need because hypercalcemia increases quickly after treatment is
stopped. This fact makes increase a lot the cost of transplantation in these patients.
The hypothesis of this study is that subtotal parathyroidectomy by minimally invasive
surgery is superior to cinacalcet for treatment of persistent secondary HPT post renal
transplant, with minimal morbidity and significantly reduces the cost of treatment after
transplantation.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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